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Chemical Compound Review:

CHEMBL1375 5-chloro-2-hydroxy-benzoic acid

Synonyms: SureCN130605, CCRIS 4485, C70908_ALDRICH, AG-F-07190, ACMC-209hr2, ...

Diamantis, W. et al., Sofia, R.D. et al., Diamantis, W. et al.

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High impact information on AIDS018045

Meseclazone, 5-chlorosalicylic acid and acetylsalicylic acid. Comparison of their effects on in vitro and ex vivo platelet aggregation [1].
Moreover, the LD50 for 5-chlorosalicylic acid (261.0 mg/kg) is approximately 6.5 times less than that of I (1710.0 mg/kg) in the nonfasted rat [2].

Analytical, diagnostic and therapeutic context of AIDS018045

Comparative gastric ulcerogenic effects of meseclazone, 5-chlorosalicylic acid and other nonsteroidal anti-inflammatory drugs following acute and repeated oral administration to rats [3].

References

Meseclazone, 5-chlorosalicylic acid and acetylsalicylic acid. Comparison of their effects on in vitro and ex vivo platelet aggregation. Diamantis, W., Kohlhepp, W.C., Haertlein, B., Melton, J., Sofia, R.D. Thromb. Haemost. (1978) [Pubmed]
Comparative anti-inflammatory, analgesic, and antipyretic activities of 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one and 5-chlorosalicylic acid in rats. Sofia, R.D., Diamantis, W., Ludwig, B.J. Journal of pharmaceutical sciences. (1975) [Pubmed]
Comparative gastric ulcerogenic effects of meseclazone, 5-chlorosalicylic acid and other nonsteroidal anti-inflammatory drugs following acute and repeated oral administration to rats. Diamantis, W., Melton, J., Sofia, R.D., Ciofalo, V.B. Toxicol. Appl. Pharmacol. (1980) [Pubmed]

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