Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-F-26632 N-(7-hydroxy-9H-fluoren-2- yl)ethanamide

Synonyms: CHEMBL1908054, NSC-40566, LS-9699, NSC40566, CTK4H6339, ...

Harris, C. et al., Stark, K.L. et al., Holmes, T.J. et al.

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High impact information on NSC 40566

NiCl2, 12.67%; 70H2AAF, 16.56%; TPA, 19.72%; HGF, 23.73%; DCB, 24.59%; positive apoptotic control (taxol) 26.94% [1].
Valproic acid (VPA), cytochalasin D (CD) and 7-hydroxy-2-acetylaminofluorene (7-OH-AAF) each caused abnormal closure of the anterior neuropore in rat embryos cultured in vitro in the absence of an exogenous bioactivation system [2].

Analytical, diagnostic and therapeutic context of NSC 40566

Intra-amniotic microinjections of large quantities (3500 ng) of 7-hydroxy-2-acetylaminofluorene (7-OH-AAF) or APAP failed to produce the specific neurulation defect [3].

References

Differential effects of non-genotoxic carcinogens and proliferating agents on cell growth, survival and apoptosis in hepatic cells in vitro. Holmes, T.J., Rainsford, K.D. Life Sci. (2001) [Pubmed]
Glutathione status and the incidence of neural tube defects elicited by direct acting teratogens in vitro. Harris, C., Stark, K.L., Juchau, M.R. Teratology (1988) [Pubmed]
Dysmorphogenesis elicited by microinjected acetaminophen analogs and metabolites in rat embryos cultured in vitro. Stark, K.L., Lee, Q.P., Namkung, M.J., Harris, C., Juchau, M.R. J. Pharmacol. Exp. Ther. (1990) [Pubmed]

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