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Chemical Compound Review

ACMC-1AFVL     2-hydroxy-3-methyl-butanoic acid

Synonyms: AG-F-42618, CHEMBL1162479, ACMC-209e7s, CHEBI:60645, HMDB00407, ...
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Disease relevance of NSC 227884


Analytical, diagnostic and therapeutic context of NSC 227884

  • Examination of urine samples by capillary column gas chromatography and mass spectrometry showed the presence of 2-hydroxyisovaleric acid together with trace amounts of the three branched-chain 2-keto acids in five patients with lactic and ketoacidosis [1].


  1. The occurrence of 2-hydroxyisovaleric acid in patients with lactic acidosis and ketoacidosis. Landaas, S., Jakobs, C. Clin. Chim. Acta (1977) [Pubmed]
  2. Hydroxy acid metabolites of branched-chain amino acids in amniotic fluid. Jakobs, C., Sweetman, L., Nyhan, W.L. Clin. Chim. Acta (1984) [Pubmed]
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