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MeSH Review

Acidosis, Lactic

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Analytical, diagnostic and therapeutic context of Acidosis, Lactic


  1. A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group. Stacpoole, P.W., Wright, E.C., Baumgartner, T.G., Bersin, R.M., Buchalter, S., Curry, S.H., Duncan, C.A., Harman, E.M., Henderson, G.N., Jenkinson, S. N. Engl. J. Med. (1992) [Pubmed]
  2. Vasodilator therapy of idiopathic lactic acidosis. Taradash, M.R., Jacobson, L.B. N. Engl. J. Med. (1975) [Pubmed]
  3. Impairment of mitochondrial transcription termination by a point mutation associated with the MELAS subgroup of mitochondrial encephalomyopathies. Hess, J.F., Parisi, M.A., Bennett, J.L., Clayton, D.A. Nature (1991) [Pubmed]
  4. Increased risk of stroke in patients with the A12308G polymorphism in mitochondria. Pulkes, T., Sweeney, M.G., Hanna, M.G. Lancet (2000) [Pubmed]
  5. Iron-overload disease in infants involving fetal growth retardation, lactic acidosis, liver haemosiderosis, and aminoaciduria. Fellman, V., Rapola, J., Pihko, H., Varilo, T., Raivio, K.O. Lancet (1998) [Pubmed]
  6. The SR protein SC35 is responsible for aberrant splicing of the E1alpha pyruvate dehydrogenase mRNA in a case of mental retardation with lactic acidosis. Gabut, M., Miné, M., Marsac, C., Brivet, M., Tazi, J., Soret, J. Mol. Cell. Biol. (2005) [Pubmed]
  7. Acute lactic acidosis with Wernicke's encephalopathy due to acute thiamine deficiency. Chadda, K., Raynard, B., Antoun, S., Thyrault, M., Nitenberg, G. Intensive care medicine. (2002) [Pubmed]
  8. Severe lactic acidosis due to thiamine deficiency in a patient with B-cell leukemia/lymphoma on total parenteral nutrition during high-dose methotrexate therapy. Svahn, J., Schiaffino, M.C., Caruso, U., Calvillo, M., Minniti, G., Dufour, C. J. Pediatr. Hematol. Oncol. (2003) [Pubmed]
  9. 2-Ketoglutarate dehydrogenase deficiency, a rare cause of primary hyperlactataemia: report of a new case. Guffon, N., Lopez-Mediavilla, C., Dumoulin, R., Mousson, B., Godinot, C., Carrier, H., Collombet, J.M., Divry, P., Mathieu, M., Guibaud, P. J. Inherit. Metab. Dis. (1993) [Pubmed]
  10. Mitochondrial DNA sequence analysis of patients with 'atypical psychosis'. Kazuno, A.A., Munakata, K., Mori, K., Tanaka, M., Nanko, S., Kunugi, H., Umekage, T., Tochigi, M., Kohda, K., Sasaki, T., Akiyama, T., Washizuka, S., Kato, N., Kato, T. Psychiatry and clinical neurosciences. (2005) [Pubmed]
  11. Exercise intolerance due to mutations in the cytochrome b gene of mitochondrial DNA. Andreu, A.L., Hanna, M.G., Reichmann, H., Bruno, C., Penn, A.S., Tanji, K., Pallotti, F., Iwata, S., Bonilla, E., Lach, B., Morgan-Hughes, J., DiMauro, S. N. Engl. J. Med. (1999) [Pubmed]
  12. Lactic acidosis in patients with diabetes treated with metformin. Misbin, R.I., Green, L., Stadel, B.V., Gueriguian, J.L., Gubbi, A., Fleming, G.A. N. Engl. J. Med. (1998) [Pubmed]
  13. Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B. McKenzie, R., Fried, M.W., Sallie, R., Conjeevaram, H., Di Bisceglie, A.M., Park, Y., Savarese, B., Kleiner, D., Tsokos, M., Luciano, C. N. Engl. J. Med. (1995) [Pubmed]
  14. Treatment of lactic acidosis with dichloroacetate. Stacpoole, P.W., Harman, E.M., Curry, S.H., Baumgartner, T.G., Misbin, R.I. N. Engl. J. Med. (1983) [Pubmed]
  15. Propylene glycol intoxication and lactic acidosis. Cate, J.C., Hedrick, R. N. Engl. J. Med. (1980) [Pubmed]
  16. Stimulation of lactate production by administration of bicarbonate in a patient with a solid neoplasm and lactic acidosis. Fraley, D.S., Adler, S., Bruns, F.J., Zett, B. N. Engl. J. Med. (1980) [Pubmed]
  17. Absence of pyruvate decarboxylase activity in man: a cause of congenital lactic acidosis. Farrell, D.F., Clark, A.F., Scott, C.R., Wennberg, R.P. Science (1975) [Pubmed]
  18. Evidence for a detrimental effect of bicarbonate therapy in hypoxic lactic acidosis. Graf, H., Leach, W., Arieff, A.I. Science (1985) [Pubmed]
  19. Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease. Kirino, Y., Yasukawa, T., Ohta, S., Akira, S., Ishihara, K., Watanabe, K., Suzuki, T. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  20. Acquisition of the wobble modification in mitochondrial tRNALeu(CUN) bearing the G12300A mutation suppresses the MELAS molecular defect. Kirino, Y., Yasukawa, T., Marjavaara, S.K., Jacobs, H.T., Holt, I.J., Watanabe, K., Suzuki, T. Hum. Mol. Genet. (2006) [Pubmed]
  21. Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis. Grad, L.I., Lemire, B.D. Hum. Mol. Genet. (2004) [Pubmed]
  22. Pathogenesis and management of lactic acidosis. Kreisberg, R.A. Annu. Rev. Med. (1984) [Pubmed]
  23. Spontaneous hypoglycemia in chronic renal failure. Rutsky, E.A., McDaniel, H.G., Tharpe, D.L., Alred, G., Pek, S. Arch. Intern. Med. (1978) [Pubmed]
  24. Inhibition of lactate removal by ketone bodies in rat liver. Evidence for a quantitatively important role of the plasma membrane lactate transporter in lactate metabolism. Metcalfe, H.K., Monson, J.P., Welch, S.G., Cohen, R.D. J. Clin. Invest. (1986) [Pubmed]
  25. Strongly succinate dehydrogenase-reactive blood vessels in muscles from patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes. Hasegawa, H., Matsuoka, T., Goto, Y., Nonaka, I. Ann. Neurol. (1991) [Pubmed]
  26. Skeletal muscle adaptation to endurance training in patients with chronic obstructive pulmonary disease. Maltais, F., LeBlanc, P., Simard, C., Jobin, J., Bérubé, C., Bruneau, J., Carrier, L., Belleau, R. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  27. Visuoperceptual function in visual agnosia. Mendez, M.F. Neurology (1988) [Pubmed]
  28. Effects of methylprednisolone on extracellular lactic acidosis and amino acids after severe compression injury of rat spinal cord. Farooque, M., Hillered, L., Holtz, A., Olsson, Y. J. Neurochem. (1996) [Pubmed]
  29. A new disease-related mutation for mitochondrial encephalopathy lactic acidosis and strokelike episodes (MELAS) syndrome affects the ND4 subunit of the respiratory complex I. Lertrit, P., Noer, A.S., Jean-Francois, M.J., Kapsa, R., Dennett, X., Thyagarajan, D., Lethlean, K., Byrne, E., Marzuki, S. Am. J. Hum. Genet. (1992) [Pubmed]
  30. GRACILE syndrome, a lethal metabolic disorder with iron overload, is caused by a point mutation in BCS1L. Visapää, I., Fellman, V., Vesa, J., Dasvarma, A., Hutton, J.L., Kumar, V., Payne, G.S., Makarow, M., Van Coster, R., Taylor, R.W., Turnbull, D.M., Suomalainen, A., Peltonen, L. Am. J. Hum. Genet. (2002) [Pubmed]
  31. Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. Wang, D.S., Kusuhara, H., Kato, Y., Jonker, J.W., Schinkel, A.H., Sugiyama, Y. Mol. Pharmacol. (2003) [Pubmed]
  32. Deficiency of dihydrolipoyl dehydrogenase (a component of the pyruvate and alpha-ketoglutarate dehydrogenase complexes): a cause of congenital chronic lactic acidosis in infancy. Robinson, B.H., Taylor, J., Sherwood, W.G. Pediatr. Res. (1977) [Pubmed]
  33. Lactic acidosis and developmental delay due to deficiency of E3 binding protein (protein X) of the pyruvate dehydrogenase complex. Ramadan, D.G., Head, R.A., Al-Tawari, A., Habeeb, Y., Zaki, M., Al-Ruqum, F., Besley, G.T., Wraith, J.E., Brown, R.M., Brown, G.K. J. Inherit. Metab. Dis. (2004) [Pubmed]
  34. Treatment of metformin-associated lactic acidosis with closed recirculation bicarbonate-buffered hemodialysis. Chalopin, J.M., Tanter, Y., Besancenot, J.F., Cabanne, J.F., Rifle, G. Arch. Intern. Med. (1984) [Pubmed]
  35. Brain tissue pH after global brain ischemia and barbiturate loading in rats. Nemoto, E.M., Frinak, S. Stroke (1981) [Pubmed]
  36. A transcranial doppler ultrasonography study of cerebrovascular CO2 reactivity in mitochondrial encephalomyopathy. Kodaka, R., Itagaki, Y., Matsumoto, M., Nagai, T., Okada, S. Stroke (1996) [Pubmed]
  37. Influence of lactate accumulation on calcium content of ischemic and postischemic brain. MacMillan, V. J. Cereb. Blood Flow Metab. (1989) [Pubmed]
  38. Role of metformin accumulation in metformin-associated lactic acidosis. Lalau, J.D., Lacroix, C., Compagnon, P., de Cagny, B., Rigaud, J.P., Bleichner, G., Chauveau, P., Dulbecco, P., Guérin, C., Haegy, J.M. Diabetes Care (1995) [Pubmed]
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