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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SNUPN  -  snurportin 1

Homo sapiens

Synonyms: KPNBL, RNA U transporter 1, RNUT1, SNURPORTIN-1, SPN1, ...
 
 
 
 
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Disease relevance of SNUPN

  • Human SPN1 was overexpressed as a GST-fusion protein in Escherichia coli and purified to homogeneity [1].
 

High impact information on SNUPN

  • Purification, crystallization and preliminary crystallographic data of the m3G cap-binding domain of human snRNP import factor snurportin 1 [1].
  • The nuclear import of spliceosomal UsnRNPs is mediated by the transport adaptor snurportin 1 (SPN1), which specifically recognizes the 2,2,7-trimethylguanosine (m(3)G) cap at the 5' end of UsnRNAs [1].
 

Analytical, diagnostic and therapeutic context of SNUPN

  • Since full-length SPN1 did not crystallize, limited proteolysis experiments were performed and stable digestion products were analyzed for functionality with respect to m(3)G cap-binding activity and subsequently used for crystallization trials [1].

References

  1. Purification, crystallization and preliminary crystallographic data of the m3G cap-binding domain of human snRNP import factor snurportin 1. Strasser, A., Dickmanns, A., Schmidt, U., Penka, E., Urlaub, H., Sekine, M., Lührmann, R., Ficner, R. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
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