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Gene Review

MARCH6  -  membrane-associated ring finger (C3HC4) 6,...

Homo sapiens

Synonyms: DOA10, Doa10 homolog, E3 ubiquitin-protein ligase MARCH6, KIAA0597, MARCH-VI, ...
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High impact information on MARCH6


Analytical, diagnostic and therapeutic context of MARCH6

  • We show that the isolated TEB4 RING domain catalyses ubiquitin ligation in vitro in a reaction that is ubiquitin Lys48-specific and involves UBC7 (ubiquitin-conjugating enzyme 7) [1].


  1. TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum. Hassink, G., Kikkert, M., van Voorden, S., Lee, S.J., Spaapen, R., van Laar, T., Coleman, C.S., Bartee, E., Früh, K., Chau, V., Wiertz, E. Biochem. J. (2005) [Pubmed]
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