High impact information on SIRPB1

• SIRP beta 1/DAP12 complex formation was required for efficient cell-surface expression of SIRP beta 1 [1].
• SIRP alpha and SIRP beta thus have complementary roles in signal regulation and may conspire to tune the response to a stimulus [2].
• DAP-12 possesses immunoreceptor tyrosine-based activation motifs within its cytoplasmic domain that are thought to link SIRP beta to activating machinery [2].
• In osteoclast precursor cells FcRgamma-associated receptors include osteoclast-associated receptor and paired immunoglobulinlike receptor A, while triggering receptor expressed in myeloid cells 2 and signal-regulatory protein beta1 preferentially associate with DAP12 [3].

Anatomical context of SIRPB1

• Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells [1].

References