Gene Review:
TYROBP - TYRO protein tyrosine kinase binding protein
Homo sapiens
Synonyms:
DAP12, DNAX-activation protein 12, KAR-associated protein, KARAP, Killer-activating receptor-associated protein, ...
- Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts. Paloneva, J., Kestilä, M., Wu, J., Salminen, A., Böhling, T., Ruotsalainen, V., Hakola, P., Bakker, A.B., Phillips, J.H., Pekkarinen, P., Lanier, L.L., Timonen, T., Peltonen, L. Nat. Genet. (2000)
- Modulation of hepatic granulomatous responses by transgene expression of DAP12 or TREM-1-Ig molecules. Nochi, H., Aoki, N., Oikawa, K., Yanai, M., Takiyama, Y., Atsuta, Y., Kobayashi, H., Sato, K., Tateno, M., Matsuno, T., Katagiri, M., Xing, Z., Kimura, S. Am. J. Pathol. (2003)
- DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features. Paloneva, J., Mandelin, J., Kiialainen, A., Bohling, T., Prudlo, J., Hakola, P., Haltia, M., Konttinen, Y.T., Peltonen, L. J. Exp. Med. (2003)
- Massive inflammatory syndrome and lymphocytic immunodeficiency in KARAP/DAP12-transgenic mice. Lucas, M., Daniel, L., Tomasello, E., Guia, S., Horschowski, N., Aoki, N., Figarella-Branger, D., Gomez, S., Vivier, E. Eur. J. Immunol. (2002)
- Enhanced tryptophan catabolism in the absence of the molecular adapter DAP12. Orabona, C., Tomasello, E., Fallarino, F., Bianchi, R., Volpi, C., Bellocchio, S., Romani, L., Fioretti, M.C., Vivier, E., Puccetti, P., Grohmann, U. Eur. J. Immunol. (2005)
- Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia. Sessa, G., Podini, P., Mariani, M., Meroni, A., Spreafico, R., Sinigaglia, F., Colonna, M., Panina, P., Meldolesi, J. Eur. J. Neurosci. (2004)
- Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells. Lanier, L.L., Corliss, B.C., Wu, J., Leong, C., Phillips, J.H. Nature (1998)
- Association of DAP12 with activating CD94/NKG2C NK cell receptors. Lanier, L.L., Corliss, B., Wu, J., Phillips, J.H. Immunity (1998)
- Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. Paloneva, J., Manninen, T., Christman, G., Hovanes, K., Mandelin, J., Adolfsson, R., Bianchin, M., Bird, T., Miranda, R., Salmaggi, A., Tranebjaerg, L., Konttinen, Y., Peltonen, L. Am. J. Hum. Genet. (2002)
- Selective activation of the c-Jun NH2-terminal protein kinase signaling pathway by stimulatory KIR in the absence of KARAP/DAP12 in CD4+ T cells. Snyder, M.R., Lucas, M., Vivier, E., Weyand, C.M., Goronzy, J.J. J. Exp. Med. (2003)
- Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells. Dietrich, J., Cella, M., Seiffert, M., Bühring, H.J., Colonna, M. J. Immunol. (2000)
- Syk regulation of phosphoinositide 3-kinase-dependent NK cell function. Jiang, K., Zhong, B., Gilvary, D.L., Corliss, B.C., Vivier, E., Hong-Geller, E., Wei, S., Djeu, J.Y. J. Immunol. (2002)
- Association of signal-regulatory proteins beta with KARAP/DAP-12. Tomasello, E., Cant, C., Bühring, H.J., Vély, F., André, P., Seiffert, M., Ullrich, A., Vivier, E. Eur. J. Immunol. (2000)
- Contrasting roles of DAP10 and KARAP/DAP12 signaling adaptors in activation of the RBL-2H3 leukemic mast cell line. Anfossi, N., Lucas, M., Diefenbach, A., Bühring, H.J., Raulet, D., Tomasello, E., Vivier, E. Eur. J. Immunol. (2003)
- The assembly of diverse immune receptors is focused on a polar membrane-embedded interaction site. Feng, J., Call, M.E., Wucherpfennig, K.W. PLoS Biol. (2006)
- NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence. Campbell, K.S., Yusa, S., Kikuchi-Maki, A., Catina, T.L. J. Immunol. (2004)
- TREMs in the immune system and beyond. Colonna, M. Nat. Rev. Immunol. (2003)
- Negative regulation of leucocyte functions by CD33-related siglecs. Avril, T., Attrill, H., Zhang, J., Raper, A., Crocker, P.R. Biochem. Soc. Trans. (2006)
- Nasu-Hakola disease (polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy--PLOSL): a dementia associated with bone cystic lesions. From clinical to genetic and molecular aspects. Bianchin, M.M., Capella, H.M., Chaves, D.L., Steindel, M., Grisard, E.C., Ganev, G.G., da Silva Júnior, J.P., Neto Evaldo, S., Poffo, M.A., Walz, R., Carlotti Júnior, C.G., Sakamoto, A.C. Cell. Mol. Neurobiol. (2004)
- Stimulatory killer Ig-like receptors modulate T cell activation through DAP12-dependent and DAP12-independent mechanisms. Snyder, M.R., Nakajima, T., Leibson, P.J., Weyand, C.M., Goronzy, J.J. J. Immunol. (2004)
- Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells. Karimi, M., Cao, T.M., Baker, J.A., Verneris, M.R., Soares, L., Negrin, R.S. J. Immunol. (2005)
- Decreased DAP12 expression in natural killer lymphocytes from patients with systemic lupus erythematosus is associated with increased transcript mutations. Toyabe, S., Kaneko, U., Uchiyama, M. J. Autoimmun. (2004)
- Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells. Bakker, A.B., Baker, E., Sutherland, G.R., Phillips, J.H., Lanier, L.L. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Cloning and characterization of a novel activating Ly49 closely related to Ly49A. Makrigiannis, A.P., Gosselin, P., Mason, L.H., Taylor, L.S., McVicar, D.W., Ortaldo, J.R., Anderson, S.K. J. Immunol. (1999)