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Gene Review

birA  -  biotin--protein ligase

Escherichia coli CFT073

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Disease relevance of birA

  • When birA protein was co-expressed in E. coli biotin was incorporated almost completely into a model protein which carried these recognition tags at its C-terminus [1].

High impact information on birA


Biological context of birA

  • Secondly, we tested in vivo and in vitro site-directed biotinylation with two different tags, consisting of either 15 (AviTag) or 72 amino acids (BioEase tag), which serve as a substrate for bacterial biotin ligase birA [1].


  1. Evaluation of two novel tag-based labelling technologies for site-specific modification of proteins. Tirat, A., Freuler, F., Stettler, T., Mayr, L.M., Leder, L. Int. J. Biol. Macromol. (2006) [Pubmed]
  2. Conservation of the biotin regulon and the BirA regulatory signal in Eubacteria and Archaea. Rodionov, D.A., Mironov, A.A., Gelfand, M.S. Genome Res. (2002) [Pubmed]
  3. Nonenzymatic biotinylation of a biotin carboxyl carrier protein: unusual reactivity of the physiological target lysine. Streaker, E.D., Beckett, D. Protein Sci. (2006) [Pubmed]
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