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Gene Review

rpsO  -  30S ribosomal protein S15

Escherichia coli CFT073

 
 
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Disease relevance of rpsO

  • Surprisingly, E. coli with an in-frame deletion of rpsO are viable, although at 37 degrees C this DeltarpsO strain has an exaggerated doubling time compared to its parental strain [1].
 

High impact information on rpsO

  • Comparison of the kinetics of nibbling of oligoadenylated rpsO mRNA in vivo and in vitro lead us to conclude that the rates of shortening and elongation of the oligo(A) tails detected in vivo are very slow: about 0.5-7 nucleotides per min [2].

References

  1. 30S ribosomal subunits can be assembled in vivo without primary binding ribosomal protein S15. Bubunenko, M., Korepanov, A., Court, D.L., Jagannathan, I., Dickinson, D., Chaudhuri, B.R., Garber, M.B., Culver, G.M. RNA (2006) [Pubmed]
  2. Fate of mRNA extremities generated by intrinsic termination: detailed analysis of reactions catalyzed by ribonuclease II and poly(A) polymerase. Folichon, M., Marujo, P.E., Arluison, V., Le Derout, J., Pellegrini, O., Hajnsdorf, E., Régnier, P. Biochimie (2005) [Pubmed]
 
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