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Gene Review:

cls - cardiolipin synthetase

Pseudomonas putida KT2440

Guo, D. et al., von Wallbrunn, A. et al.

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Disease relevance of cls

Cis/trans isomerisation of unsaturated fatty acids in a cardiolipin synthase knock-out mutant of Pseudomonas putida P8 [1].
The predicted amino acid sequence has 129 identities and 100 similarities with the Escherichia coli CL synthase [2].

High impact information on cls

The B. firmus OF4 cls gene product was inserted into plasmid pET3 to form a recombinant plasmid pDG2, which overproduces CL synthase in E. coli [2].

References

Cis/trans isomerisation of unsaturated fatty acids in a cardiolipin synthase knock-out mutant of Pseudomonas putida P8. von Wallbrunn, A., Heipieper, H.J., Meinhardt, F. Appl. Microbiol. Biotechnol. (2002) [Pubmed]
Cloning of the Bacillus firmus OF4 cls gene and characterization of its gene product. Guo, D., Tropp, B.E. Biochim. Biophys. Acta (1998) [Pubmed]

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