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Disease relevance of Pseudomonas


Psychiatry related information on Pseudomonas

  • Permissiveness to L. pneumophila was not the consequence of a general defect in the microbicidal capacities because killing of a temperature-sensitive mutant of Pseudomonas aeruginosa was normal in DN PKC-alpha-overexpressing RAW 264.7 clones [6].
  • We investigated the in vitro and in vivo effects of a combination of a beta-lactam (ceftazidime) and a beta-lactamase inhibitor (dicloxacillin) to synergistically kill a ceftazidime-resistant variant, Pseudomonas aeruginosa PA-48, which overproduces type Id cephalosporinase constitutively [7].
  • The local skin tissue concentration of 50% and 100% gentamicin sulphate, loaded full IPNs (i.e., Ax-1 and Ax-2), was found to be higher (20+/-2mug/g) than the minimum bactericidal concentration for Staphylococcus aureus (1.2mug/g) and Pseudomonas aeruginosa (10mug/g), respectively, for a study time of 60 days [8].
  • One death in the limited-spectrum empirical antimicrobial therapy group was due to autopsy-proved disseminated Pseudomonas aeruginosa (blood, peritoneum, lung, and pleural fluid) that was resistant to cefoxitin, and the other was associated with peritonitis due to cefoxitin-resistant Enterobacter cloacae [9].

High impact information on Pseudomonas

  • Two Pseudomonas syringae type III effectors inhibit RIN4-regulated basal defense in Arabidopsis [10].
  • In Arabidopsis, RPM1 confers resistance against Pseudomonas syringae expressing either of two sequence unrelated type III effectors, AvrRpm1 or AvrB [11].
  • The Pto serine/threonine kinase of tomato confers resistance to speck disease by recognizing strains of Pseudomonas syringae that express the protein AvrPto [12].
  • In tomato, resistance to Pseudomonas syringae pv. tomato (Pst) strains expressing the avirulence gene avrPto requires the presence of at least two host genes, designated Pto and Prf [13].
  • Barnase toxin: a new chimeric toxin composed of pseudomonas exotoxin A and barnase [14].

Chemical compound and disease context of Pseudomonas


Biological context of Pseudomonas


Anatomical context of Pseudomonas


Gene context of Pseudomonas


Analytical, diagnostic and therapeutic context of Pseudomonas


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  3. Nosocomial meningitis and bacteremia due to contaminated amphotericin B. Sarubbi, F.A., Wilson, B., Lee, M., Brokopp, C. JAMA (1978) [Pubmed]
  4. Transfer of a cathelicidin peptide antibiotic gene restores bacterial killing in a cystic fibrosis xenograft model. Bals, R., Weiner, D.J., Meegalla, R.L., Wilson, J.M. J. Clin. Invest. (1999) [Pubmed]
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  7. Bactericidal interactions of a beta-lactam and beta-lactamase inhibitors in experimental Pseudomonas aeruginosa endocarditis caused by a constitutive overproducer of type Id beta-lactamase. Bayer, A.S., Selecky, M., Babel, K., Hirano, L., Yih, J., Parr, T.R. Antimicrob. Agents Chemother. (1987) [Pubmed]
  8. Studies on biodegradation and release of gentamicin sulphate from interpenetrating network hydrogels based on poly(acrylic acid) and gelatin: in vitro and in vivo. Changez, M., Koul, V., Krishna, B., Dinda, A.K., Choudhary, V. Biomaterials (2004) [Pubmed]
  9. Management of intra-abdominal infections. The case for intraoperative cultures and comprehensive broad-spectrum antibiotic coverage. The Canadian Intra-abdominal Infection Study Group. Christou, N.V., Turgeon, P., Wassef, R., Rotstein, O., Bohnen, J., Potvin, M. Archives of surgery (Chicago, Ill. : 1960) (1996) [Pubmed]
  10. Two Pseudomonas syringae type III effectors inhibit RIN4-regulated basal defense in Arabidopsis. Kim, M.G., da Cunha, L., McFall, A.J., Belkhadir, Y., DebRoy, S., Dangl, J.L., Mackey, D. Cell (2005) [Pubmed]
  11. RIN4 interacts with Pseudomonas syringae type III effector molecules and is required for RPM1-mediated resistance in Arabidopsis. Mackey, D., Holt, B.F., Wiig, A., Dangl, J.L. Cell (2002) [Pubmed]
  12. Two distinct Pseudomonas effector proteins interact with the Pto kinase and activate plant immunity. Kim, Y.J., Lin, N.C., Martin, G.B. Cell (2002) [Pubmed]
  13. Tomato Prf is a member of the leucine-rich repeat class of plant disease resistance genes and lies embedded within the Pto kinase gene cluster. Salmeron, J.M., Oldroyd, G.E., Rommens, C.M., Scofield, S.R., Kim, H.S., Lavelle, D.T., Dahlbeck, D., Staskawicz, B.J. Cell (1996) [Pubmed]
  14. Barnase toxin: a new chimeric toxin composed of pseudomonas exotoxin A and barnase. Prior, T.I., FitzGerald, D.J., Pastan, I. Cell (1991) [Pubmed]
  15. Pseudomonas aeruginosa exotoxin A. Pollack, M. N. Engl. J. Med. (1980) [Pubmed]
  16. Pseudobacteremia caused by povidone-iodine solution contaminated with Pseudomonas cepacia. Craven, D.E., Moody, B., Connolly, M.G., Kollisch, N.R., Stottmeier, K.D., McCabe, W.R. N. Engl. J. Med. (1981) [Pubmed]
  17. Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation. Joo, H., Lin, Z., Arnold, F.H. Nature (1999) [Pubmed]
  18. Isochorismate synthase is required to synthesize salicylic acid for plant defence. Wildermuth, M.C., Dewdney, J., Wu, G., Ausubel, F.M. Nature (2001) [Pubmed]
  19. Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts. Grassmé, H., Jendrossek, V., Riehle, A., von Kürthy, G., Berger, J., Schwarz, H., Weller, M., Kolesnick, R., Gulbins, E. Nat. Med. (2003) [Pubmed]
  20. Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence. Park, P.W., Pier, G.B., Hinkes, M.T., Bernfield, M. Nature (2001) [Pubmed]
  21. Phagocytosis of unopsonized Pseudomonas aeruginosa by murine macrophages is a two-step process requiring glucose. Speert, D.P., Gordon, S. J. Clin. Invest. (1992) [Pubmed]
  22. Safety and immunogenicity of a Pseudomonas aeruginosa O-polysaccharide toxin A conjugate vaccine in humans. Cryz, S.J., Fürer, E., Cross, A.S., Wegmann, A., Germanier, R., Sadoff, J.C. J. Clin. Invest. (1987) [Pubmed]
  23. Protein domains and conformational changes in the activation of RepA, a DNA replication initiator. Giraldo, R., Andreu, J.M., Díaz-Orejas, R. EMBO J. (1998) [Pubmed]
  24. Crystal structure of AmiC: the controller of transcription antitermination in the amidase operon of Pseudomonas aeruginosa. Pearl, L., O'Hara, B., Drew, R., Wilson, S. EMBO J. (1994) [Pubmed]
  25. Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8. DiMango, E., Zar, H.J., Bryan, R., Prince, A. J. Clin. Invest. (1995) [Pubmed]
  26. Characterization of immunotoxins active against ovarian cancer cell lines. Pirker, R., FitzGerald, D.J., Hamilton, T.C., Ozols, R.F., Laird, W., Frankel, A.E., Willingham, M.C., Pastan, I. J. Clin. Invest. (1985) [Pubmed]
  27. Interaction of the Pseudomonas aeruginosa secretory products pyocyanin and pyochelin generates hydroxyl radical and causes synergistic damage to endothelial cells. Implications for Pseudomonas-associated tissue injury. Britigan, B.E., Roeder, T.L., Rasmussen, G.T., Shasby, D.M., McCormick, M.L., Cox, C.D. J. Clin. Invest. (1992) [Pubmed]
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  29. A component of innate immunity prevents bacterial biofilm development. Singh, P.K., Parsek, M.R., Greenberg, E.P., Welsh, M.J. Nature (2002) [Pubmed]
  30. The C5a chemoattractant receptor mediates mucosal defence to infection. Höpken, U.E., Lu, B., Gerard, N.P., Gerard, C. Nature (1996) [Pubmed]
  31. Excessive inflammatory response of cystic fibrosis mice to bronchopulmonary infection with Pseudomonas aeruginosa. Heeckeren, A., Walenga, R., Konstan, M.W., Bonfield, T., Davis, P.B., Ferkol, T. J. Clin. Invest. (1997) [Pubmed]
  32. Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria. Kim, S.C., Tonkonogy, S.L., Albright, C.A., Tsang, J., Balish, E.J., Braun, J., Huycke, M.M., Sartor, R.B. Gastroenterology (2005) [Pubmed]
  33. Pseudomonas exotoxin-mediated selection yields cells with altered expression of low-density lipoprotein receptor-related protein. FitzGerald, D.J., Fryling, C.M., Zdanovsky, A., Saelinger, C.B., Kounnas, M., Winkles, J.A., Strickland, D., Leppla, S. J. Cell Biol. (1995) [Pubmed]
  34. Proteins of the cystic fibrosis respiratory tract. Fragmented immunoglobulin G opsonic antibody causing defective opsonophagocytosis. Fick, R.B., Naegel, G.P., Squier, S.U., Wood, R.E., Gee, J.B., Reynolds, H.Y. J. Clin. Invest. (1984) [Pubmed]
  35. Neutral thiol as a proximal ligand to ferrous heme iron: implications for heme proteins that lose cysteine thiolate ligation on reduction. Perera, R., Sono, M., Sigman, J.A., Pfister, T.D., Lu, Y., Dawson, J.H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  36. Inhibition of antibody response to Pseudomonas exotoxin and an immunotoxin containing Pseudomonas exotoxin by 15-deoxyspergualin in mice. Pai, L.H., FitzGerald, D.J., Tepper, M., Schacter, B., Spitalny, G., Pastan, I. Cancer Res. (1990) [Pubmed]
  37. In situ expression of interleukin-4 (IL-4) receptors in human brain tumors and cytotoxicity of a recombinant IL-4 cytotoxin in primary glioblastoma cell cultures. Joshi, B.H., Leland, P., Asher, A., Prayson, R.A., Varricchio, F., Puri, R.K. Cancer Res. (2001) [Pubmed]
  38. Methioninase cancer gene therapy with selenomethionine as suicide prodrug substrate. Miki, K., Xu, M., Gupta, A., Ba, Y., Tan, Y., Al-Refaie, W., Bouvet, M., Makuuchi, M., Moossa, A.R., Hoffman, R.M. Cancer Res. (2001) [Pubmed]
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