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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

COG5  -  component of oligomeric golgi complex 5

Homo sapiens

Synonyms: 13S Golgi transport complex 90 kDa subunit, CDG2I, COG complex subunit 5, Component of oligomeric Golgi complex 5, Conserved oligomeric Golgi complex subunit 5, ...
 
 
 
 
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High impact information on COG5

  • Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells [1].
  • Large-scale immunoprecipitation of rat liver cytosol with immobilized anti-Sec34 antibodies has co-immunoprecipitated GTC-90 and ldlBp, two peripheral Golgi proteins previously shown to exist in separate protein complexes [2].
 

Anatomical context of COG5

 

Other interactions of COG5

  • These results suggest that Sec34, GTC-90, and ldlBp/ldlCp are part of the same protein complex(es) that regulates diverse aspects of Golgi function, including transport from the ER to the Golgi apparatus [2].

References

  1. Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells. Oka, T., Vasile, E., Penman, M., Novina, C.D., Dykxhoorn, D.M., Ungar, D., Hughson, F.M., Krieger, M. J. Biol. Chem. (2005) [Pubmed]
  2. Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp. Loh, E., Hong, W. J. Biol. Chem. (2002) [Pubmed]
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