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Gene Review

Coro2a  -  coronin, actin binding protein 2A

Mus musculus

Synonyms: 9030208C03Rik, AI563590, Coronin-2A, IR10, coronin 4
 
 
 
 
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Disease relevance of Coro2a

  • When challenged with known inducers of keratinocyte IL-1 synthesis and release, skin of IR10 mice exhibited an exaggerated inflammatory response, characterized by epidermal hyperplasia and an acute dermal inflammatory cell infiltrate [1].
 

High impact information on Coro2a

  • To confirm that these changes were indeed related to IL-1 mediated activation pathways, IR10 mice were crossed to a distinct line of transgenic mice that overexpress 17-kD IL-l alpha in basal keratinocytes [1].

References

 
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