The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Mice, Transgenic

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Mice, Transgenic


Psychiatry related information on Mice, Transgenic


High impact information on Mice, Transgenic

  • Studies in patients and transgenic mice have demonstrated that both AQP2 and AQP3 are essential for urinary concentration [11].
  • The importance of estrogen in both males and females was also demonstrated in the laboratory in transgenic mice in which the aromatase gene was inactivated [12].
  • Just as transgenic mice were produced in which estrogen receptors had been inactivated and we thought that we were about to understand the role of estrogen receptors in physiology and pathology, it was found that there was not one but two distinct and functional estrogen receptors, now called ER alpha and ER beta [12].
  • Experiments with transgenic mice suggest that OT acts as a luteotrophic hormone opposing the luteolytic action of PGF(2 alpha) [13].
  • Experiments using a transgenic mouse expressing creatine kinase in liver to understand ATP catabolism and regulation of oxidative phosphorylation are discussed [14].

Chemical compound and disease context of Mice, Transgenic


Biological context of Mice, Transgenic


Anatomical context of Mice, Transgenic


Associations of Mice, Transgenic with chemical compounds

  • To test this possibility and to resolve the relative roles of liver and beta cell GLK in maintaining glucose levels, we have generated mice completely deficient in GLK and transgenic mice in which GLK is expressed only in beta cells [30].
  • We generated transgenic mice expressing H/K-ATPase beta subunit in which this motif's tyrosine residue is mutated to alanine [31].
  • In adult transgenic mice, 2 weeks of subcutaneous treatment with the antiviral agent ganciclovir preferentially ablated transgene-expressing, GFAP-positive glia from the jejunum and ileum, causing a fulminating and fatal jejuno-ileitis [32].
  • We have used the involucrin promoter to express functional human integrin subunits alpha 2, alpha 5, and beta 1 in the suprabasal epidermal layers of transgenic mice [15].
  • Two mutations which have been successfully used to generate transgenic mice that develop an ALS-like syndrome are glycine 85 to arginine (G85R) and glycine 93 to alanine (G93A) with the mutant SOD1 allele overexpressed in a normal mouse genetic background [33].

Gene context of Mice, Transgenic


Analytical, diagnostic and therapeutic context of Mice, Transgenic


  1. Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice. Matsui, Y., Halter, S.A., Holt, J.T., Hogan, B.L., Coffey, R.J. Cell (1990) [Pubmed]
  2. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Balthasar, N., Dalgaard, L.T., Lee, C.E., Yu, J., Funahashi, H., Williams, T., Ferreira, M., Tang, V., McGovern, R.A., Kenny, C.D., Christiansen, L.M., Edelstein, E., Choi, B., Boss, O., Aschkenasi, C., Zhang, C.Y., Mountjoy, K., Kishi, T., Elmquist, J.K., Lowell, B.B. Cell (2005) [Pubmed]
  3. Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Muller, W.J., Sinn, E., Pattengale, P.K., Wallace, R., Leder, P. Cell (1988) [Pubmed]
  4. Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice. Hanna, Z., Kay, D.G., Rebai, N., Guimond, A., Jothy, S., Jolicoeur, P. Cell (1998) [Pubmed]
  5. The relationship of IL-4- and IFN gamma-producing T cells studied by lineage ablation of IL-4-producing cells. Kamogawa, Y., Minasi, L.A., Carding, S.R., Bottomly, K., Flavell, R.A. Cell (1993) [Pubmed]
  6. Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Lazarov, O., Robinson, J., Tang, Y.P., Hairston, I.S., Korade-Mirnics, Z., Lee, V.M., Hersh, L.B., Sapolsky, R.M., Mirnics, K., Sisodia, S.S. Cell (2005) [Pubmed]
  7. Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Chen, M., Ona, V.O., Li, M., Ferrante, R.J., Fink, K.B., Zhu, S., Bian, J., Guo, L., Farrell, L.A., Hersch, S.M., Hobbs, W., Vonsattel, J.P., Cha, J.H., Friedlander, R.M. Nat. Med. (2000) [Pubmed]
  8. Neurological illness in transgenic mice expressing a prion protein with an insertional mutation. Chiesa, R., Piccardo, P., Ghetti, B., Harris, D.A. Neuron (1998) [Pubmed]
  9. Dehydration activates an NF-kappaB-driven, COX2-dependent survival mechanism in renal medullary interstitial cells. Hao, C.M., Yull, F., Blackwell, T., Kömhoff, M., Davis, L.S., Breyer, M.D. J. Clin. Invest. (2000) [Pubmed]
  10. Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5. Ahlijanian, M.K., Barrezueta, N.X., Williams, R.D., Jakowski, A., Kowsz, K.P., McCarthy, S., Coskran, T., Carlo, A., Seymour, P.A., Burkhardt, J.E., Nelson, R.B., McNeish, J.D. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  11. Aquaporins in the kidney: from molecules to medicine. Nielsen, S., Frøkiaer, J., Marples, D., Kwon, T.H., Agre, P., Knepper, M.A. Physiol. Rev. (2002) [Pubmed]
  12. Mechanisms of estrogen action. Nilsson, S., Mäkelä, S., Treuter, E., Tujague, M., Thomsen, J., Andersson, G., Enmark, E., Pettersson, K., Warner, M., Gustafsson, J.A. Physiol. Rev. (2001) [Pubmed]
  13. The oxytocin receptor system: structure, function, and regulation. Gimpl, G., Fahrenholz, F. Physiol. Rev. (2001) [Pubmed]
  14. Insights into cellular energy metabolism from transgenic mice. Koretsky, A.P. Physiol. Rev. (1995) [Pubmed]
  15. Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis. Carroll, J.M., Romero, M.R., Watt, F.M. Cell (1995) [Pubmed]
  16. HIV protease inhibitors protect apolipoprotein B from degradation by the proteasome: a potential mechanism for protease inhibitor-induced hyperlipidemia. Liang, J.S., Distler, O., Cooper, D.A., Jamil, H., Deckelbaum, R.J., Ginsberg, H.N., Sturley, S.L. Nat. Med. (2001) [Pubmed]
  17. The mammary gland iodide transporter is expressed during lactation and in breast cancer. Tazebay, U.H., Wapnir, I.L., Levy, O., Dohan, O., Zuckier, L.S., Zhao, Q.H., Deng, H.F., Amenta, P.S., Fineberg, S., Pestell, R.G., Carrasco, N. Nat. Med. (2000) [Pubmed]
  18. 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration. Waza, M., Adachi, H., Katsuno, M., Minamiyama, M., Sang, C., Tanaka, F., Inukai, A., Doyu, M., Sobue, G. Nat. Med. (2005) [Pubmed]
  19. Tissue-specific and ectopic expression of genes introduced into transgenic mice by retroviruses. Soriano, P., Cone, R.D., Mulligan, R.C., Jaenisch, R. Science (1986) [Pubmed]
  20. Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context-dependent manner. Festenstein, R., Sharghi-Namini, S., Fox, M., Roderick, K., Tolaini, M., Norton, T., Saveliev, A., Kioussis, D., Singh, P. Nat. Genet. (1999) [Pubmed]
  21. The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation. Sham, M.H., Vesque, C., Nonchev, S., Marshall, H., Frain, M., Gupta, R.D., Whiting, J., Wilkinson, D., Charnay, P., Krumlauf, R. Cell (1993) [Pubmed]
  22. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Sawada, S., Scarborough, J.D., Killeen, N., Littman, D.R. Cell (1994) [Pubmed]
  23. SOX9 directly regulates the type-II collagen gene. Bell, D.M., Leung, K.K., Wheatley, S.C., Ng, L.J., Zhou, S., Ling, K.W., Sham, M.H., Koopman, P., Tam, P.P., Cheah, K.S. Nat. Genet. (1997) [Pubmed]
  24. Tissue-specific posttranslational processing of pre-prosomatostatin encoded by a metallothionein-somatostatin fusion gene in transgenic mice. Low, M.J., Hammer, R.E., Goodman, R.H., Habener, J.F., Palmiter, R.D., Brinster, R.L. Cell (1985) [Pubmed]
  25. A role for CaMKII in T cell memory. Bui, J.D., Calbo, S., Hayden-Martinez, K., Kane, L.P., Gardner, P., Hedrick, S.M. Cell (2000) [Pubmed]
  26. The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice. Langdon, W.Y., Harris, A.W., Cory, S., Adams, J.M. Cell (1986) [Pubmed]
  27. Mice expressing activated CaMKII lack low frequency LTP and do not form stable place cells in the CA1 region of the hippocampus. Rotenberg, A., Mayford, M., Hawkins, R.D., Kandel, E.R., Muller, R.U. Cell (1996) [Pubmed]
  28. c-fos expression interferes with thymus development in transgenic mice. Rüther, U., Müller, W., Sumida, T., Tokuhisa, T., Rajewsky, K., Wagner, E.F. Cell (1988) [Pubmed]
  29. Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo. Ikeda, H., Yamaguchi, M., Sugai, S., Aze, Y., Narumiya, S., Kakizuka, A. Nat. Genet. (1996) [Pubmed]
  30. Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis. Grupe, A., Hultgren, B., Ryan, A., Ma, Y.H., Bauer, M., Stewart, T.A. Cell (1995) [Pubmed]
  31. A tyrosine-based signal targets H/K-ATPase to a regulated compartment and is required for the cessation of gastric acid secretion. Courtois-Coutry, N., Roush, D., Rajendran, V., McCarthy, J.B., Geibel, J., Kashgarian, M., Caplan, M.J. Cell (1997) [Pubmed]
  32. Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. Bush, T.G., Savidge, T.C., Freeman, T.C., Cox, H.J., Campbell, E.A., Mucke, L., Johnson, M.H., Sofroniew, M.V. Cell (1998) [Pubmed]
  33. Mutations in SOD1 associated with amyotrophic lateral sclerosis cause novel protein interactions. Kunst, C.B., Mezey, E., Brownstein, M.J., Patterson, D. Nat. Genet. (1997) [Pubmed]
  34. A common human skin tumour is caused by activating mutations in beta-catenin. Chan, E.F., Gat, U., McNiff, J.M., Fuchs, E. Nat. Genet. (1999) [Pubmed]
  35. Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice. Manley, K., Shirley, T.L., Flaherty, L., Messer, A. Nat. Genet. (1999) [Pubmed]
  36. Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila. Diez, E., Lee, S.H., Gauthier, S., Yaraghi, Z., Tremblay, M., Vidal, S., Gros, P. Nat. Genet. (2003) [Pubmed]
  37. Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Stoffers, D.A., Zinkin, N.T., Stanojevic, V., Clarke, W.L., Habener, J.F. Nat. Genet. (1997) [Pubmed]
  38. Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA. Reddy, P.H., Williams, M., Charles, V., Garrett, L., Pike-Buchanan, L., Whetsell, W.O., Miller, G., Tagle, D.A. Nat. Genet. (1998) [Pubmed]
  39. Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Bibb, J.A., Chen, J., Taylor, J.R., Svenningsson, P., Nishi, A., Snyder, G.L., Yan, Z., Sagawa, Z.K., Ouimet, C.C., Nairn, A.C., Nestler, E.J., Greengard, P. Nature (2001) [Pubmed]
  40. Accelerated transport and maturation of lysosomal alpha-galactosidase A in Fabry lymphoblasts by an enzyme inhibitor. Fan, J.Q., Ishii, S., Asano, N., Suzuki, Y. Nat. Med. (1999) [Pubmed]
  41. Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus. Taki, S., Meiering, M., Rajewsky, K. Science (1993) [Pubmed]
  42. Protection against atherogenesis in mice mediated by human apolipoprotein A-IV. Duverger, N., Tremp, G., Caillaud, J.M., Emmanuel, F., Castro, G., Fruchart, J.C., Steinmetz, A., Denèfle, P. Science (1996) [Pubmed]
WikiGenes - Universities