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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Mice, Transgenic

 
 
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Disease relevance of Mice, Transgenic

 

Psychiatry related information on Mice, Transgenic

 

High impact information on Mice, Transgenic

  • Studies in patients and transgenic mice have demonstrated that both AQP2 and AQP3 are essential for urinary concentration [11].
  • The importance of estrogen in both males and females was also demonstrated in the laboratory in transgenic mice in which the aromatase gene was inactivated [12].
  • Just as transgenic mice were produced in which estrogen receptors had been inactivated and we thought that we were about to understand the role of estrogen receptors in physiology and pathology, it was found that there was not one but two distinct and functional estrogen receptors, now called ER alpha and ER beta [12].
  • Experiments with transgenic mice suggest that OT acts as a luteotrophic hormone opposing the luteolytic action of PGF(2 alpha) [13].
  • Experiments using a transgenic mouse expressing creatine kinase in liver to understand ATP catabolism and regulation of oxidative phosphorylation are discussed [14].
 

Chemical compound and disease context of Mice, Transgenic

 

Biological context of Mice, Transgenic

 

Anatomical context of Mice, Transgenic

 

Associations of Mice, Transgenic with chemical compounds

  • To test this possibility and to resolve the relative roles of liver and beta cell GLK in maintaining glucose levels, we have generated mice completely deficient in GLK and transgenic mice in which GLK is expressed only in beta cells [30].
  • We generated transgenic mice expressing H/K-ATPase beta subunit in which this motif's tyrosine residue is mutated to alanine [31].
  • In adult transgenic mice, 2 weeks of subcutaneous treatment with the antiviral agent ganciclovir preferentially ablated transgene-expressing, GFAP-positive glia from the jejunum and ileum, causing a fulminating and fatal jejuno-ileitis [32].
  • We have used the involucrin promoter to express functional human integrin subunits alpha 2, alpha 5, and beta 1 in the suprabasal epidermal layers of transgenic mice [15].
  • Two mutations which have been successfully used to generate transgenic mice that develop an ALS-like syndrome are glycine 85 to arginine (G85R) and glycine 93 to alanine (G93A) with the mutant SOD1 allele overexpressed in a normal mouse genetic background [33].
 

Gene context of Mice, Transgenic

 

Analytical, diagnostic and therapeutic context of Mice, Transgenic

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