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Gene Review

WDR4  -  WD repeat domain 4

Homo sapiens

Synonyms: TRM82, TRMT82, WD repeat-containing protein 4, tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
 
 
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High impact information on WDR4

  • This functional two-protein family appears to be retained in eukaryotes, as expression of both corresponding human proteins, METTL1 and WDR4, is required for m7G-methyltransferase activity [1].
  • Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein [2].
  • The WDR4 gene spans 37 kb and is divided into 11 coding exons [2].

References

  1. Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. Alexandrov, A., Martzen, M.R., Phizicky, E.M. RNA (2002) [Pubmed]
  2. Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein. Michaud, J., Kudoh, J., Berry, A., Bonne-Tamir, B., Lalioti, M.D., Rossier, C., Shibuya, K., Kawasaki, K., Asakawa, S., Minoshima, S., Shimizu, N., Antonarakis, S.E., Scott, H.S. Genomics (2000) [Pubmed]
 
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