The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

Ir2  -  immune response 2

Mus musculus

Synonyms: Ir-2
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Ir2

  • Another gene affecting this trait is closely linked to the H-3 and Ir-2 loci on the second chromosome [1].
  • Selective reversal of H-2 linked genetic unresponsiveness to lysozymes. I. Non-H-2 gene(s) closely linked to the Ir-2 locus on chromosome 2 permit(s) an antilysozyme response in H-2b mice [2].
  • Ir2 on mouse chromosome 2 controls parasite numbers and lymphocellular infiltration in liver of Leishmania donovani infected mice (DeTolla LJ et al. Immunogenetics 10: 353, 1980).
  • Ir2 co-localize with Lmr14 that controls hepatomegaly, splenomegaly [3], IgE and cytokine levels after infection with Leishmania major in mice [4] [5].

References

  1. Genes in mice that affect susceptibility to cortisone-induced cleft palate are closely linked to Ir genes on chromosomes 2 and 17. Gasser, D.L., Mele, L., Lees, D.D., Goldman, A.S. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  2. Selective reversal of H-2 linked genetic unresponsiveness to lysozymes. I. Non-H-2 gene(s) closely linked to the Ir-2 locus on chromosome 2 permit(s) an antilysozyme response in H-2b mice. Sadegh-Nasseri, S., Kipp, D.E., Taylor, B.A., Miller, A., Sercarz, E. Immunogenetics (1984) [Pubmed]
  3. Different genetic control of cutaneous and visceral disease after Leishmania major infection in mice. Vladimirov, V., Badalová, J., Svobodová, M., Havelková, H., Hart, A.A., Blazková, H., Demant, P., Lipoldová, M. Infect. Immun. (2003) [Pubmed]
  4. Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis. Lipoldová, M., Demant, P. Nat. Rev. Genet. (2006) [Pubmed]
  5. Genetics of susceptibility to leishmaniasis in mice: four novel loci and functional heterogeneity of gene effects. Havelková, H., Badalová, J., Svobodová, M., Vojtíková, J., Kurey, I., Vladimirov, V., Demant, P., Lipoldová, M. Genes. Immun. (2006) [Pubmed]
 
WikiGenes - Universities