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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NUDT4  -  nudix (nucleoside diphosphate linked...

Homo sapiens

Synonyms: DIPP-2, DIPP2, DIPP2alpha, DIPP2beta, Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2, ...
 
 
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High impact information on NUDT4

  • The hDIPP3 mRNA is preferentially expressed in testis, accompanied by relatively weak expression in the brain, contrasting with hDIPP1 and hDIPP2 which are widely expressed [1].
  • Thus, 'intron boundary skidding' by spliceosomes provides a mechanism for yielding both hDIPP2alpha and hDIPP2beta mRNAs [2].
  • Only one of these genes could potentially give rise to our previously characterized hDIPP2beta mRNA; the other gene has several sequence differences and, in any case, is likely a processed pseudogene [2].
 

Biological context of NUDT4

 

Other interactions of NUDT4

 

Analytical, diagnostic and therapeutic context of NUDT4

  • However, sequence analysis of a third hDIPP2 gene (at 12q21) places the Gln86 CAG codon within an AGCAG pentamer, offering adjacent, alternate intronic 3'-boundaries [2].

References

  1. An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase. Hidaka, K., Caffrey, J.J., Hua, L., Zhang, T., Falck, J.R., Nickel, G.C., Carrel, L., Barnes, L.D., Shears, S.B. J. Biol. Chem. (2002) [Pubmed]
  2. Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2. Caffrey, J.J., Shears, S.B. Gene (2001) [Pubmed]
  3. Molecular cloning of a novel isoform of diphosphoinositol polyphosphate phosphohydrolase: a potential target of lithium therapy. Hua, L.V., Green, M., Warsh, J.J., Li, P.P. Neuropsychopharmacology (2001) [Pubmed]
  4. Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family. Caffrey, J.J., Safrany, S.T., Yang, X., Shears, S.B. J. Biol. Chem. (2000) [Pubmed]
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