Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Szv1 - seizure severity 1

Mus musculus

Synonyms: Kasz6

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Disease relevance of Szv1

Seizure severity was expressed by the following scoring scale: (0) no abnormal behavior; (1) myoclonus; (2) running bouncing (RB) clonus; (3) tonic hind limb extension (THE) [1].

High impact information on Szv1

Seizure severity paralleled kainate dosage [2].
Seizure severity was determined by (1) the duration of tonic hindlimb extensor (THE) phase and by (2) mortality due to electroconvulsions [3].
Seizure severity was expressed by the following scoring scale: 0 (no abnormal behavior, NAB); 1 (myoclonus, M); 2 (running bouncing clonus, RBC); 3 (tonic hindlimb extension, THE) [4].

Anatomical context of Szv1

Seizure severity was assessed by the duration of tonic hindlimb extensor phase and mortality due to convulsions [5].

References

Sex differences in sensitivity to seizures elicited by pentylenetetrazol in mice. Medina, A.E., Manhães, A.C., Schmidt, S.L. Pharmacol. Biochem. Behav. (2001) [Pubmed]
Neuronal stress and injury in C57/BL mice after systemic kainic acid administration. Hu, R.Q., Koh, S., Torgerson, T., Cole, A.J. Brain Res. (1998) [Pubmed]
On the mechanism of anticonvulsant effect of tramadol in mice. Manocha, A., Sharma, K.K., Mediratta, P.K. Pharmacol. Biochem. Behav. (2005) [Pubmed]
The effects of callosal agenesis on the susceptibility to seizures elicited by pentylenetetrazol in BALB/cCF mice. Medina, A.E., Manhães, A.C., Schmidt, S.L. Pharmacol. Biochem. Behav. (2002) [Pubmed]
Possible mechanism involved in the anticonvulsant action of butorphanol in mice. Manocha, A., Sharma, K.K., Mediratta, P.K. Pharmacol. Biochem. Behav. (2003) [Pubmed]

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