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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GALNT6  -  polypeptide N-acetylgalactosaminyltransfer...

Homo sapiens

Synonyms: GALNAC-T6, GalNAc-T6, GalNAcT6, Polypeptide GalNAc transferase 6, Polypeptide N-acetylgalactosaminyltransferase 6, ...
 
 
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High impact information on GALNT6

  • The genomic organizations of GALNT3 and GALNT6 are identical with the coding regions placed in 10 exons, but the genes are localized differently at 2q31 and 12q13, respectively [1].
  • In all samples, apical GalNAc-T2 was absent, and GalNAc-T6 was entirely absent [2].
  • Binding of antibody to GalNAc-T6 was restricted exclusively to conjunctival goblet cells [2].

References

  1. Cloning and characterization of a close homologue of human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6. Evidence for genetic but not functional redundancy. Bennett, E.P., Hassan, H., Mandel, U., Hollingsworth, M.A., Akisawa, N., Ikematsu, Y., Merkx, G., van Kessel, A.G., Olofsson, S., Clausen, H. J. Biol. Chem. (1999) [Pubmed]
  2. The cell-layer- and cell-type-specific distribution of GalNAc-transferases in the ocular surface epithelia is altered during keratinization. Argüeso, P., Tisdale, A., Mandel, U., Letko, E., Foster, C.S., Gipson, I.K. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
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