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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RASSF8  -  Ras association (RalGDS/AF-6) domain...

Homo sapiens

Synonyms: C12orf2, Carcinoma-associated protein HOJ-1, HOJ1, HoJ-1, Ras association domain-containing protein 8
 
 
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Disease relevance of RASSF8

  • Expression of RASSF8 protein by transfected lung cancer cells led to inhibition of anchorage-independent growth in soft agar in A549 cells and reduction of clonogenic activity in NCI-H520 cells [1].
  • Analysis of the RASSF8 transcript revealed a complex expression pattern of 5'-UTR mRNA isoforms in normal lung and in lung adenocarcinomas (ADCAs), with no apparent differences [1].
 

High impact information on RASSF8

  • Identification of RASSF8 as a candidate lung tumor suppressor gene [1].
  • The RASSF8 gene, which maps close to the KRAS2 gene, contains a RAS-associated domain and encodes a protein that is evolutionarily conserved from fish to humans [1].

References

  1. Identification of RASSF8 as a candidate lung tumor suppressor gene. Falvella, F.S., Manenti, G., Spinola, M., Pignatiello, C., Conti, B., Pastorino, U., Dragani, T.A. Oncogene (2006) [Pubmed]
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