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Genes, Tumor Suppressor

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  1. TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. Kuramochi, M., Fukuhara, H., Nobukuni, T., Kanbe, T., Maruyama, T., Ghosh, H.P., Pletcher, M., Isomura, M., Onizuka, M., Kitamura, T., Sekiya, T., Reeves, R.H., Murakami, Y. Nat. Genet. (2001) [Pubmed]
  2. BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. Bochar, D.A., Wang, L., Beniya, H., Kinev, A., Xue, Y., Lane, W.S., Wang, W., Kashanchi, F., Shiekhattar, R. Cell (2000) [Pubmed]
  3. Restriction of ocular fundus lesions to a specific subgroup of APC mutations in adenomatous polyposis coli patients. Olschwang, S., Tiret, A., Laurent-Puig, P., Muleris, M., Parc, R., Thomas, G. Cell (1993) [Pubmed]
  4. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Buchkovich, K., Duffy, L.A., Harlow, E. Cell (1989) [Pubmed]
  5. Brief report: a familial syndrome of pancreatic cancer and melanoma with a mutation in the CDKN2 tumor-suppressor gene. Whelan, A.J., Bartsch, D., Goodfellow, P.J. N. Engl. J. Med. (1995) [Pubmed]
  6. Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B. Astrinidis, A., Senapedis, W., Coleman, T.R., Henske, E.P. J. Biol. Chem. (2003) [Pubmed]
  7. Human chromosomal localization, tissue/tumor expression, and regulatory function of the ets family gene EHF. Kleinbaum, L.A., Duggan, C., Ferreira, E., Coffey, G.P., Butticè, G., Burton, F.H. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  8. Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1. Rosenbauer, F., Owens, B.M., Yu, L., Tumang, J.R., Steidl, U., Kutok, J.L., Clayton, L.K., Wagner, K., Scheller, M., Iwasaki, H., Liu, C., Hackanson, B., Akashi, K., Leutz, A., Rothstein, T.L., Plass, C., Tenen, D.G. Nat. Genet. (2006) [Pubmed]
  9. The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis. Yokoyama, A., Somervaille, T.C., Smith, K.S., Rozenblatt-Rosen, O., Meyerson, M., Cleary, M.L. Cell (2005) [Pubmed]
  10. Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer. Sun, X., Frierson, H.F., Chen, C., Li, C., Ran, Q., Otto, K.B., Cantarel, B.L., Cantarel, B.M., Vessella, R.L., Gao, A.C., Petros, J., Miura, Y., Simons, J.W., Dong, J.T. Nat. Genet. (2005) [Pubmed]
  11. Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia. Yu, L., Liu, C., Vandeusen, J., Becknell, B., Dai, Z., Wu, Y.Z., Raval, A., Liu, T.H., Ding, W., Mao, C., Liu, S., Smith, L.T., Lee, S., Rassenti, L., Marcucci, G., Byrd, J., Caligiuri, M.A., Plass, C. Nat. Genet. (2005) [Pubmed]
  12. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Olive, K.P., Tuveson, D.A., Ruhe, Z.C., Yin, B., Willis, N.A., Bronson, R.T., Crowley, D., Jacks, T. Cell (2004) [Pubmed]
  13. Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Ylikorkala, A., Rossi, D.J., Korsisaari, N., Luukko, K., Alitalo, K., Henkemeyer, M., Mäkelä, T.P. Science (2001) [Pubmed]
  14. Trichloroethylene exposure and specific somatic mutations in patients with renal cell carcinoma. Brauch, H., Weirich, G., Hornauer, M.A., Störkel, S., Wöhl, T., Brüning, T. J. Natl. Cancer Inst. (1999) [Pubmed]
  15. Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27. Cesari, R., Martin, E.S., Calin, G.A., Pentimalli, F., Bichi, R., McAdams, H., Trapasso, F., Drusco, A., Shimizu, M., Masciullo, V., D'Andrilli, G., Scambia, G., Picchio, M.C., Alder, H., Godwin, A.K., Croce, C.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  16. Folate deficiency delays the onset but increases the incidence of leukemia in Friend virus-infected mice. Koury, M.J., Park, D.J., Martincic, D., Horne, D.W., Kravtsov, V., Whitlock, J.A., del Pilar Aguinaga, M., Kopsombut, P. Blood (1997) [Pubmed]
  17. Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder. Le, D.T., Kong, N., Zhu, Y., Lauchle, J.O., Aiyigari, A., Braun, B.S., Wang, E., Kogan, S.C., Le Beau, M.M., Parada, L., Shannon, K.M. Blood (2004) [Pubmed]
  18. Absence of ST7 mutations in tumor-derived cell lines and tumors. Hughes, K.A., Hurlstone, A.F., Tobias, E.S., McFarlane, R., Black, D.M. Nat. Genet. (2001) [Pubmed]
  19. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Quelle, D.E., Zindy, F., Ashmun, R.A., Sherr, C.J. Cell (1995) [Pubmed]
  20. Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms. Malkin, D., Jolly, K.W., Barbier, N., Look, A.T., Friend, S.H., Gebhardt, M.C., Andersen, T.I., Børresen, A.L., Li, F.P., Garber, J. N. Engl. J. Med. (1992) [Pubmed]
  21. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Hakem, R., de la Pompa, J.L., Sirard, C., Mo, R., Woo, M., Hakem, A., Wakeham, A., Potter, J., Reitmair, A., Billia, F., Firpo, E., Hui, C.C., Roberts, J., Rossant, J., Mak, T.W. Cell (1996) [Pubmed]
  22. Drosophila p53 binds a damage response element at the reaper locus. Brodsky, M.H., Nordstrom, W., Tsang, G., Kwan, E., Rubin, G.M., Abrams, J.M. Cell (2000) [Pubmed]
  23. Germ-line mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms. Malkin, D., Friend, S.H., Li, F.P., Strong, L.C. N. Engl. J. Med. (1997) [Pubmed]
  24. WT-1 is required for early kidney development. Kreidberg, J.A., Sariola, H., Loring, J.M., Maeda, M., Pelletier, J., Housman, D., Jaenisch, R. Cell (1993) [Pubmed]
  25. A major palmitoylated membrane protein of human erythrocytes shows homology to yeast guanylate kinase and to the product of a Drosophila tumor suppressor gene. Bryant, P.J., Woods, D.F. Cell (1992) [Pubmed]
  26. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Dameron, K.M., Volpert, O.V., Tainsky, M.A., Bouck, N. Science (1994) [Pubmed]
  27. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Ravi, R., Mookerjee, B., Bhujwalla, Z.M., Sutter, C.H., Artemov, D., Zeng, Q., Dillehay, L.E., Madan, A., Semenza, G.L., Bedi, A. Genes Dev. (2000) [Pubmed]
  28. The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Woods, D.F., Bryant, P.J. Cell (1991) [Pubmed]
  29. ERM-Merlin and EBP50 protein families in plasma membrane organization and function. Bretscher, A., Chambers, D., Nguyen, R., Reczek, D. Annu. Rev. Cell Dev. Biol. (2000) [Pubmed]
  30. Alterations of the PPP2R1B gene in human lung and colon cancer. Wang, S.S., Esplin, E.D., Li, J.L., Huang, L., Gazdar, A., Minna, J., Evans, G.A. Science (1998) [Pubmed]
  31. 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes. Rideout, W.M., Coetzee, G.A., Olumi, A.F., Jones, P.A. Science (1990) [Pubmed]
  32. Membrane-actin microfilament connections: an increasing diversity of players related to band 4.1. Arpin, M., Algrain, M., Louvard, D. Curr. Opin. Cell Biol. (1994) [Pubmed]
  33. An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Hemann, M.T., Fridman, J.S., Zilfou, J.T., Hernando, E., Paddison, P.J., Cordon-Cardo, C., Hannon, G.J., Lowe, S.W. Nat. Genet. (2003) [Pubmed]
  34. TSC2 mediates cellular energy response to control cell growth and survival. Inoki, K., Zhu, T., Guan, K.L. Cell (2003) [Pubmed]
  35. DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Robert, M.F., Morin, S., Beaulieu, N., Gauthier, F., Chute, I.C., Barsalou, A., MacLeod, A.R. Nat. Genet. (2003) [Pubmed]
  36. Notch1 functions as a tumor suppressor in mouse skin. Nicolas, M., Wolfer, A., Raj, K., Kummer, J.A., Mill, P., van Noort, M., Hui, C.C., Clevers, H., Dotto, G.P., Radtke, F. Nat. Genet. (2003) [Pubmed]
  37. Truncating mutations of RB1CC1 in human breast cancer. Chano, T., Kontani, K., Teramoto, K., Okabe, H., Ikegawa, S. Nat. Genet. (2002) [Pubmed]
  38. CTS1: a p53-derived chimeric tumor suppressor gene with enhanced in vitro apoptotic properties. Conseiller, E., Debussche, L., Landais, D., Venot, C., Maratrat, M., Sierra, V., Tocque, B., Bracco, L. J. Clin. Invest. (1998) [Pubmed]
  39. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice. Tang, X., Kim, A.L., Feith, D.J., Pegg, A.E., Russo, J., Zhang, H., Aszterbaum, M., Kopelovich, L., Epstein, E.H., Bickers, D.R., Athar, M. J. Clin. Invest. (2004) [Pubmed]
  40. Increased expression of mutant forms of p53 oncogene in primary lung cancer. Iggo, R., Gatter, K., Bartek, J., Lane, D., Harris, A.L. Lancet (1990) [Pubmed]
  41. The molecular epidemiology of p53 gene mutations in human breast cancer. Hartmann, A., Blaszyk, H., Kovach, J.S., Sommer, S.S. Trends Genet. (1997) [Pubmed]
  42. ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin. Haskins, J., Gu, L., Wittchen, E.S., Hibbard, J., Stevenson, B.R. J. Cell Biol. (1998) [Pubmed]
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