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Gene Review

FKBP9  -  FK506 binding protein 9, 63 kDa

Homo sapiens

Synonyms: 63 kDa FK506-binding protein, 63 kDa FKBP, FK506-binding protein 9, FKBP-63, FKBP-9, ...
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High impact information on FKBP9

  • These analyses suggest that the FKBP multigene family emerged early in the evolutionary history of eukaryotes, and during that time some members, including the FKBP65 gene, have experienced gene elongation by means of PPIase domain duplication [1].
  • This isomerization activity is inhibited by FK506. mFKBP60 binds Ca2+ in vitro, presumably by its C-terminal EF-hand Ca2+ binding motif, and is phosphorylated in vivo. hFKBP60 has been mapped to 7p12 and/or 7p14 by fluorescence in situ hybridization (FISH) [2].


  1. Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family. Patterson, C.E., Gao, J., Rooney, A.P., Davis, E.C. Genomics (2002) [Pubmed]
  2. Biochemical analysis of mouse FKBP60, a novel member of the FKPB family. Shadidy, M., Caubit, X., Olsen, R., Seternes, O.M., Moens, U., Krauss, S. Biochim. Biophys. Acta (1999) [Pubmed]
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