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Gene Review:

TWF2 - twinfilin actin-binding protein 2

Homo sapiens

Synonyms: A6-related protein, A6RP, A6r, MSTP011, PTK9L, ...

Rohwer, A. et al., Berkenblit, A. et al.

Berkenblit, Matulonis, Kroener, Dezube, Lam, Cuasay, Brünner, Jones, Silverman, Gold,

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Disease relevance of TWF2

A6-related toxicities were limited to grades 1 and 2 adverse effects including local injection site reactions [1].

High impact information on TWF2

The deduced amino acid sequence (349 amino acids) of the A6-related protein (A6rp) contained potential actin-binding sites and ATP-binding sites [2].

Analytical, diagnostic and therapeutic context of TWF2

A polyclonal anti-(A6rp) was raised in rabbits and used for the identification of A6rp by immunoblotting [2].

References

A6, a urokinase plasminogen activator (uPA)-derived peptide in patients with advanced gynecologic cancer: a phase I trial. Berkenblit, A., Matulonis, U.A., Kroener, J.F., Dezube, B.J., Lam, G.N., Cuasay, L.C., Brünner, N., Jones, T.R., Silverman, M.H., Gold, M.A. Gynecol. Oncol. (2005) [Pubmed]
Cloning, expression and characterization of an A6-related protein. Rohwer, A., Kittstein, W., Marks, F., Gschwendt, M. Eur. J. Biochem. (1999) [Pubmed]

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TWF2	Bos taurus
twf2	Danio rerio
TWF2	Gallus gallus
Twf2	Mus musculus
TWF2	Pan troglodytes
Twf2	Rattus norvegicus
twf2	Xenopus (Silurana) tropicalis

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