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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Drug Toxicity

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Disease relevance of Drug Toxicity


Psychiatry related information on Drug Toxicity


High impact information on Drug Toxicity


Chemical compound and disease context of Drug Toxicity


Biological context of Drug Toxicity


Anatomical context of Drug Toxicity


Gene context of Drug Toxicity

  • Under the appropriate conditions, such human TNF mutants are expected to induce less systemic toxicity in man, while still exerting their direct antitumour effect [29].
  • Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor [30].
  • TNF, PC, and FPS levels were normal during episodes of cyclosporine toxicity and viral infection.(ABSTRACT TRUNCATED AT 400 WORDS)[31]
  • These results demonstrate that the absence of HO-2 is associated with induction of HO-1 and increased oxygen toxicity in vivo, apparently due to accumulation of lung iron [32].
  • The results show that expression of elevated levels of CuZnSOD decreases pulmonary oxygen toxicity and associated histologic damage and mortality [33].

Analytical, diagnostic and therapeutic context of Drug Toxicity


  1. Protective effect of the bispiperazinedione ICRF-187 against doxorubicin-induced cardiac toxicity in women with advanced breast cancer. Speyer, J.L., Green, M.D., Kramer, E., Rey, M., Sanger, J., Ward, C., Dubin, N., Ferrans, V., Stecy, P., Zeleniuch-Jacquotte, A. N. Engl. J. Med. (1988) [Pubmed]
  2. Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. National Institute of Allergy and Infectious Diseases Mycoses Study Group. Walsh, T.J., Finberg, R.W., Arndt, C., Hiemenz, J., Schwartz, C., Bodensteiner, D., Pappas, P., Seibel, N., Greenberg, R.N., Dummer, S., Schuster, M., Holcenberg, J.S. N. Engl. J. Med. (1999) [Pubmed]
  3. A pilot study of low-dose zidovudine in human immunodeficiency virus infection. Collier, A.C., Bozzette, S., Coombs, R.W., Causey, D.M., Schoenfeld, D.A., Spector, S.A., Pettinelli, C.B., Davies, G., Richman, D.D., Leedom, J.M. N. Engl. J. Med. (1990) [Pubmed]
  4. Role of S-adenosylhomocysteine in adenosinemediated toxicity in cultured mouse T lymphoma cells. Kredich, N.M., Martin, D.V. Cell (1977) [Pubmed]
  5. Evidence for liver disease preceding amino acid abnormalities in hereditary tyrosinemia. Hostetter, M.K., Levy, H.L., Winter, H.S., Knight, G.J., Haddow, J.E. N. Engl. J. Med. (1983) [Pubmed]
  6. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J.S., Schroeter, E.H., Schrijvers, V., Wolfe, M.S., Ray, W.J., Goate, A., Kopan, R. Nature (1999) [Pubmed]
  7. A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration. Hodgson, J.G., Agopyan, N., Gutekunst, C.A., Leavitt, B.R., LePiane, F., Singaraja, R., Smith, D.J., Bissada, N., McCutcheon, K., Nasir, J., Jamot, L., Li, X.J., Stevens, M.E., Rosemond, E., Roder, J.C., Phillips, A.G., Rubin, E.M., Hersch, S.M., Hayden, M.R. Neuron (1999) [Pubmed]
  8. Fuel-mediated teratogenesis. Use of D-mannose to modify organogenesis in the rat embryo in vivo. Buchanan, T., Freinkel, N., Lewis, N.J., Metzger, B.E., Akazawa, S. J. Clin. Invest. (1985) [Pubmed]
  9. Chronic excessive acetaminophen use and liver damage. Barker, J.D., de Carle, D.J., Anuras, S. Ann. Intern. Med. (1977) [Pubmed]
  10. Potassium homeostasis and clinical implications. Brown, R.S. Am. J. Med. (1984) [Pubmed]
  11. Vitamin A supplementation for extremely-low-birth-weight infants. National Institute of Child Health and Human Development Neonatal Research Network. Tyson, J.E., Wright, L.L., Oh, W., Kennedy, K.A., Mele, L., Ehrenkranz, R.A., Stoll, B.J., Lemons, J.A., Stevenson, D.K., Bauer, C.R., Korones, S.B., Fanaroff, A.A. N. Engl. J. Med. (1999) [Pubmed]
  12. Lack of effect of coumarin in women with lymphedema after treatment for breast cancer. Loprinzi, C.L., Kugler, J.W., Sloan, J.A., Rooke, T.W., Quella, S.K., Novotny, P., Mowat, R.B., Michalak, J.C., Stella, P.J., Levitt, R., Tschetter, L.K., Windschitl, H. N. Engl. J. Med. (1999) [Pubmed]
  13. Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. Warrick, J.M., Chan, H.Y., Gray-Board, G.L., Chai, Y., Paulson, H.L., Bonini, N.M. Nat. Genet. (1999) [Pubmed]
  14. Doxorubicin-induced cardiac toxicity. Doroshow, J.H. N. Engl. J. Med. (1991) [Pubmed]
  15. Cisplatin toxicity for erythroid precursors. Rothmann, S.A., Weick, J.K. N. Engl. J. Med. (1981) [Pubmed]
  16. Familial pyrimidinemia and pyrimidinuria associated with severe fluorouracil toxicity. Tuchman, M., Stoeckeler, J.S., Kiang, D.T., O'Dea, R.F., Ramnaraine, M.L., Mirkin, B.L. N. Engl. J. Med. (1985) [Pubmed]
  17. Methotrexate in resistant juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind, placebo-controlled trial. The Pediatric Rheumatology Collaborative Study Group and The Cooperative Children's Study Group. Giannini, E.H., Brewer, E.J., Kuzmina, N., Shaikov, A., Maximov, A., Vorontsov, I., Fink, C.W., Newman, A.J., Cassidy, J.T., Zemel, L.S. N. Engl. J. Med. (1992) [Pubmed]
  18. The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial. Richman, D.D., Fischl, M.A., Grieco, M.H., Gottlieb, M.S., Volberding, P.A., Laskin, O.L., Leedom, J.M., Groopman, J.E., Mildvan, D., Hirsch, M.S. N. Engl. J. Med. (1987) [Pubmed]
  19. Use of plasma pharmacokinetics to predict and prevent methotrexate toxicity. Stoller, R.G., Hande, K.R., Jacobs, S.A., Rosenberg, S.A., Chabner, B.A. N. Engl. J. Med. (1977) [Pubmed]
  20. Isoniazid-induced carbamazepine toxicity and vice versa: a double drug interaction. Wright, J.M., Stokes, E.F., Sweeney, V.P. N. Engl. J. Med. (1982) [Pubmed]
  21. Prediction of BCNU pulmonary toxicity in patients with malignant gliomas: an assessment of risk factors. Aronin, P.A., Mahaley, M.S., Rudnick, S.A., Dudka, L., Donohue, J.F., Selker, R.G., Moore, P. N. Engl. J. Med. (1980) [Pubmed]
  22. Images in clinical medicine. Amiodarone-induced pulmonary toxicity. Olshansky, B. N. Engl. J. Med. (1997) [Pubmed]
  23. Transgenic mice with inducible dwarfism. Borrelli, E., Heyman, R.A., Arias, C., Sawchenko, P.E., Evans, R.M. Nature (1989) [Pubmed]
  24. Killing of cultured hepatocytes by conjugates of asialofetuin and EGF linked to the A chains of ricin or diphtheria toxin. Simpson, D.L., Cawley, D.B., Herschman, H.R. Cell (1982) [Pubmed]
  25. Bone marrow toxicity of dideoxyinosine. Molina, J.M., Groopman, J.E. N. Engl. J. Med. (1989) [Pubmed]
  26. Central nervous system toxicity after liver transplantation. The role of cyclosporine and cholesterol. de Groen, P.C., Aksamit, A.J., Rakela, J., Forbes, G.S., Krom, R.A. N. Engl. J. Med. (1987) [Pubmed]
  27. Deoxyguanosine toxicity on lymphoid cells as a cause for immunosuppression in purine nucleoside phosphorylase deficiency. Chan, T.S. Cell (1978) [Pubmed]
  28. A controlled trial of fluconazole to prevent fungal infections in patients undergoing bone marrow transplantation. Goodman, J.L., Winston, D.J., Greenfield, R.A., Chandrasekar, P.H., Fox, B., Kaizer, H., Shadduck, R.K., Shea, T.C., Stiff, P., Friedman, D.J. N. Engl. J. Med. (1992) [Pubmed]
  29. Human TNF mutants with selective activity on the p55 receptor. Van Ostade, X., Vandenabeele, P., Everaerdt, B., Loetscher, H., Gentz, R., Brockhaus, M., Lesslauer, W., Tavernier, J., Brouckaert, P., Fiers, W. Nature (1993) [Pubmed]
  30. Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor. Takahashi, N., Waelput, W., Guisez, Y. J. Exp. Med. (1999) [Pubmed]
  31. Tumor necrosis factor production during human renal allograft rejection is associated with depression of plasma protein C and free protein S levels and decreased intragraft thrombomodulin expression. Tsuchida, A., Salem, H., Thomson, N., Hancock, W.W. J. Exp. Med. (1992) [Pubmed]
  32. Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2. Dennery, P.A., Spitz, D.R., Yang, G., Tatarov, A., Lee, C.S., Shegog, M.L., Poss, K.D. J. Clin. Invest. (1998) [Pubmed]
  33. Transgenic mice with expression of elevated levels of copper-zinc superoxide dismutase in the lungs are resistant to pulmonary oxygen toxicity. White, C.W., Avraham, K.B., Shanley, P.F., Groner, Y. J. Clin. Invest. (1991) [Pubmed]
  34. Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. Williams, S.D., Birch, R., Einhorn, L.H., Irwin, L., Greco, F.A., Loehrer, P.J. N. Engl. J. Med. (1987) [Pubmed]
  35. Effect of omeprazole and cimetidine on duodenal ulcer. A double-blind comparative trial. Lauritsen, K., Rune, S.J., Bytzer, P., Kelbaek, H., Jensen, K.G., Rask-Madsen, J., Bendtsen, F., Linde, J., Højlund, M., Andersen, H.H. N. Engl. J. Med. (1985) [Pubmed]
  36. Cyclosporine-associated central-nervous-system toxicity after allogeneic bone-marrow transplantation. Atkinson, K., Biggs, J., Darveniza, P., Boland, J., Concannon, A., Dodds, A. N. Engl. J. Med. (1984) [Pubmed]
  37. Risk of infection after penetrating abdominal trauma. Nichols, R.L., Smith, J.W., Klein, D.B., Trunkey, D.D., Cooper, R.H., Adinolfi, M.F., Mills, J. N. Engl. J. Med. (1984) [Pubmed]
  38. Influenza vaccination and warfarin or theophylline toxicity in nursing-home residents. Patriarca, P.A., Kendal, A.P., Stricof, R.L., Weber, J.A., Meissner, M.K., Dateno, B. N. Engl. J. Med. (1983) [Pubmed]
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