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Gene Review:

Rencd - renal cystic disease severity

Mus musculus

Guay-Woodford, L.M. et al., Guay-Woodford, L.M. et al.

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High impact information on Rencd

Whole-genome scans revealed a CAST-derived locus on distal Chr 6, near D6Mit14, that affects renal cystic disease severity [1].
Quantitative trait loci modulate renal cystic disease severity in the mouse bpk model [1].

Biological context of Rencd

We now report that the bpk mutation maps to a 1.6 CM interval on mouse Chromosome 10, and that the renal cystic disease severity in our intersubspecific intercross progeny is influenced by the genetic background [2].

References

Quantitative trait loci modulate renal cystic disease severity in the mouse bpk model. Guay-Woodford, L.M., Wright, C.J., Walz, G., Churchill, G.A. J. Am. Soc. Nephrol. (2000) [Pubmed]
Evidence that two phenotypically distinct mouse PKD mutations, bpk and jcpk, are allelic. Guay-Woodford, L.M., Bryda, E.C., Christine, B., Lindsey, J.R., Collier, W.R., Avner, E.D., D'Eustachio, P., Flaherty, L. Kidney Int. (1996) [Pubmed]

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