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Gene Review

OSBPL6  -  oxysterol binding protein-like 6

Homo sapiens

Synonyms: ORP-6, ORP6, OSBP-related protein 6, Oxysterol-binding protein-related protein 6
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High impact information on OSBPL6

  • Analysis of ORP mRNA levels in unloaded or acetylated LDL-loaded human macrophages revealed that the expression of ORP genes was not significantly affected by the loading, with the exception of ORP6, which was up-regulated 2-fold [1].
  • This revealed a minimum of six novel OSBP-related proteins, designated ORP-1 to ORP-6 [2].
  • In the F9 cells, endogenous ORP6 associated predominantly with the nuclear envelope [3].


  1. The OSBP-related protein family in humans. Lehto, M., Laitinen, S., Chinetti, G., Johansson, M., Ehnholm, C., Staels, B., Ikonen, E., Olkkonen, V.M. J. Lipid Res. (2001) [Pubmed]
  2. Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism. Laitinen, S., Olkkonen, V.M., Ehnholm, C., Ikonen, E. J. Lipid Res. (1999) [Pubmed]
  3. Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7. Lehto, M., Tienari, J., Lehtonen, S., Lehtonen, E., Olkkonen, V.M. Cell Tissue Res. (2004) [Pubmed]
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