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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Macrophages


Psychiatry related information on Macrophages


High impact information on Macrophages

  • Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on most hemopoietic cell types [11].
  • In order to discriminate between infectious agents and self, macrophages have evolved a restricted number of phagocytic receptors, like the mannose receptor, that recognize conserved motifs on pathogens [12].
  • Expression of NOS2 in macrophages is controlled by cytokines and microbial products, primarily by transcriptional induction [13].
  • NOS2 has been documented in macrophages from human, horse, cow, goat, sheep, rat, mouse, and chicken [13].
  • A counter-receptor for CD28 is the B7 molecule expressed on activated B cells, dendritic cells, and macrophages [14].

Chemical compound and disease context of Macrophages


Biological context of Macrophages


Anatomical context of Macrophages


Associations of Macrophages with chemical compounds


Gene context of Macrophages

  • Subcellular fractionation of LPS-stimulated macrophages revealed that LPS signals transduced by Tpl2 specifically promote the transport of TNF-alpha mRNA from the nucleus to the cytoplasm [34].
  • Expression of Ucp2 is robust in spleen, lung and isolated macrophages, suggesting a role for Ucp2 in immunity or inflammatory responsiveness [35].
  • We also show that LeTx-induced macrophage death requires caspase-1, which is activated in susceptible, but not resistant, macrophages after intoxication, suggesting that Nalp1b directly or indirectly activates caspase-1 in response to LeTx [36].
  • Compared to UCP1, the gene is widely expressed in adult human tissues, including tissues rich in macrophages, and it is upregulated in white fat in response to fat feeding [37].
  • Wild-type choroidal macrophages degrade C5 and IgG in eye sections of Ccl2(-/-) or Ccr2(-/-) mice [38].

Analytical, diagnostic and therapeutic context of Macrophages


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  2. HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages. Swingler, S., Mann, A., Jacqué, J., Brichacek, B., Sasseville, V.G., Williams, K., Lackner, A.A., Janoff, E.N., Wang, R., Fisher, D., Stevenson, M. Nat. Med. (1999) [Pubmed]
  3. Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase. McKinney, J.D., Höner zu Bentrup, K., Muñoz-Elías, E.J., Miczak, A., Chen, B., Chan, W.T., Swenson, D., Sacchettini, J.C., Jacobs, W.R., Russell, D.G. Nature (2000) [Pubmed]
  4. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Makowski, L., Boord, J.B., Maeda, K., Babaev, V.R., Uysal, K.T., Morgan, M.A., Parker, R.A., Suttles, J., Fazio, S., Hotamisligil, G.S., Linton, M.F. Nat. Med. (2001) [Pubmed]
  5. Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Wang, H., Liao, H., Ochani, M., Justiniani, M., Lin, X., Yang, L., Al-Abed, Y., Wang, H., Metz, C., Miller, E.J., Tracey, K.J., Ulloa, L. Nat. Med. (2004) [Pubmed]
  6. Intestinal macrophages display reduced permissiveness to human immunodeficiency virus 1 and decreased surface CCR5. Li, L., Meng, G., Graham, M.F., Shaw, G.M., Smith, P.D. Gastroenterology (1999) [Pubmed]
  7. HIV-1 Tat neurotoxicity is prevented by matrix metalloproteinase inhibitors. Johnston, J.B., Zhang, K., Silva, C., Shalinsky, D.R., Conant, K., Ni, W., Corbett, D., Yong, V.W., Power, C. Ann. Neurol. (2001) [Pubmed]
  8. Relationship between P-glycoprotein expression and cyclosporin A in kidney. An immunohistological and cell culture study. García del Moral, R., O'Valle, F., Andújar, M., Aguilar, M., Lucena, M.A., López-Hidalgo, J., Ramírez, C., Medina-Cano, M.T., Aguilar, D., Gómez-Morales, M. Am. J. Pathol. (1995) [Pubmed]
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  10. Extensive Mycobacterium bovis BCG infection of liver parenchymal cells in immunocompromised mice. Mills, J.W., Ryan, L., LaCourse, R., North, R.J. Infect. Immun. (2001) [Pubmed]
  11. Interleukin-10 and the interleukin-10 receptor. Moore, K.W., de Waal Malefyt, R., Coffman, R.L., O'Garra, A. Annu. Rev. Immunol. (2001) [Pubmed]
  12. Mechanisms of phagocytosis in macrophages. Aderem, A., Underhill, D.M. Annu. Rev. Immunol. (1999) [Pubmed]
  13. Nitric oxide and macrophage function. MacMicking, J., Xie, Q.W., Nathan, C. Annu. Rev. Immunol. (1997) [Pubmed]
  14. The role of the CD28 receptor during T cell responses to antigen. Linsley, P.S., Ledbetter, J.A. Annu. Rev. Immunol. (1993) [Pubmed]
  15. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Borovikova, L.V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G.I., Watkins, L.R., Wang, H., Abumrad, N., Eaton, J.W., Tracey, K.J. Nature (2000) [Pubmed]
  16. PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Chinetti, G., Lestavel, S., Bocher, V., Remaley, A.T., Neve, B., Torra, I.P., Teissier, E., Minnich, A., Jaye, M., Duverger, N., Brewer, H.B., Fruchart, J.C., Clavey, V., Staels, B. Nat. Med. (2001) [Pubmed]
  17. Stimulus-dependent myristoylation of a major substrate for protein kinase C. Aderem, A.A., Albert, K.A., Keum, M.M., Wang, J.K., Greengard, P., Cohn, Z.A. Nature (1988) [Pubmed]
  18. Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock. Wagner, J.A., Varga, K., Ellis, E.F., Rzigalinski, B.A., Martin, B.R., Kunos, G. Nature (1997) [Pubmed]
  19. The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Zhao, L., Moos, M.P., Gräbner, R., Pédrono, F., Fan, J., Kaiser, B., John, N., Schmidt, S., Spanbroek, R., Lötzer, K., Huang, L., Cui, J., Rader, D.J., Evans, J.F., Habenicht, A.J., Funk, C.D. Nat. Med. (2004) [Pubmed]
  20. Phagocytosis and inflammatory stimuli induce GM-CSF mRNA in macrophages through posttranscriptional regulation. Thorens, B., Mermod, J.J., Vassalli, P. Cell (1987) [Pubmed]
  21. Transmethylation reactions regulate affinity and functional activity of chemotactic factor receptors on macrophages. Pike, M.C., Snyderman, R. Cell (1982) [Pubmed]
  22. Secretory leukocyte protease inhibitor: a macrophage product induced by and antagonistic to bacterial lipopolysaccharide. Jin, F.Y., Nathan, C., Radzioch, D., Ding, A. Cell (1997) [Pubmed]
  23. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Condeelis, J., Pollard, J.W. Cell (2006) [Pubmed]
  24. Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Matsushime, H., Roussel, M.F., Ashmun, R.A., Sherr, C.J. Cell (1991) [Pubmed]
  25. Chemoattractant receptors on phagocytic cells. Snyderman, R., Pike, M.C. Annu. Rev. Immunol. (1984) [Pubmed]
  26. Fc receptor isoforms exhibit distinct abilities for coated pit localization as a result of cytoplasmic domain heterogeneity. Miettinen, H.M., Rose, J.K., Mellman, I. Cell (1989) [Pubmed]
  27. Involvement of common and cell type-specific pathways in c-fos gene control: stable induction of cAMP in macrophages. Bravo, R., Neuberg, M., Burckhardt, J., Almendral, J., Wallich, R., Müller, R. Cell (1987) [Pubmed]
  28. Stepwise reprogramming of B cells into macrophages. Xie, H., Ye, M., Feng, R., Graf, T. Cell (2004) [Pubmed]
  29. ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease. Oram, J.F., Heinecke, J.W. Physiol. Rev. (2005) [Pubmed]
  30. MacMARCKS, a novel member of the MARCKS family of protein kinase C substrates. Li, J., Aderem, A. Cell (1992) [Pubmed]
  31. HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator. Gallay, P., Swingler, S., Aiken, C., Trono, D. Cell (1995) [Pubmed]
  32. Co-regulation of type C RNA virus production and cell differentiation in myeloid leukemic cells. Liebermann, D., Sachs, L. Cell (1978) [Pubmed]
  33. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Tanaka, T., Akira, S., Yoshida, K., Umemoto, M., Yoneda, Y., Shirafuji, N., Fujiwara, H., Suematsu, S., Yoshida, N., Kishimoto, T. Cell (1995) [Pubmed]
  34. TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Dumitru, C.D., Ceci, J.D., Tsatsanis, C., Kontoyiannis, D., Stamatakis, K., Lin, J.H., Patriotis, C., Jenkins, N.A., Copeland, N.G., Kollias, G., Tsichlis, P.N. Cell (2000) [Pubmed]
  35. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Arsenijevic, D., Onuma, H., Pecqueur, C., Raimbault, S., Manning, B.S., Miroux, B., Couplan, E., Alves-Guerra, M.C., Goubern, M., Surwit, R., Bouillaud, F., Richard, D., Collins, S., Ricquier, D. Nat. Genet. (2000) [Pubmed]
  36. Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Boyden, E.D., Dietrich, W.F. Nat. Genet. (2006) [Pubmed]
  37. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Fleury, C., Neverova, M., Collins, S., Raimbault, S., Champigny, O., Levi-Meyrueis, C., Bouillaud, F., Seldin, M.F., Surwit, R.S., Ricquier, D., Warden, C.H. Nat. Genet. (1997) [Pubmed]
  38. An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Ambati, J., Anand, A., Fernandez, S., Sakurai, E., Lynn, B.C., Kuziel, W.A., Rollins, B.J., Ambati, B.K. Nat. Med. (2003) [Pubmed]
  39. Fusion of monocytes and macrophages with HIV-1 correlates with biochemical properties of CXCR4 and CCR5. Lapham, C.K., Zaitseva, M.B., Lee, S., Romanstseva, T., Golding, H. Nat. Med. (1999) [Pubmed]
  40. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Schoenberger, S.P., Toes, R.E., van der Voort, E.I., Offringa, R., Melief, C.J. Nature (1998) [Pubmed]
  41. Myelomonocytic cells are sufficient for therapeutic cell fusion in liver. Willenbring, H., Bailey, A.S., Foster, M., Akkari, Y., Dorrell, C., Olson, S., Finegold, M., Fleming, W.H., Grompe, M. Nat. Med. (2004) [Pubmed]
  42. Wound macrophages express TGF-alpha and other growth factors in vivo: analysis by mRNA phenotyping. Rappolee, D.A., Mark, D., Banda, M.J., Werb, Z. Science (1988) [Pubmed]
  43. Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase. Sturgill-Koszycki, S., Schlesinger, P.H., Chakraborty, P., Haddix, P.L., Collins, H.L., Fok, A.K., Allen, R.D., Gluck, S.L., Heuser, J., Russell, D.G. Science (1994) [Pubmed]
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