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Gene Review: 

Tbrs1  -  tuberculosis resistance 1

Mus musculus

Synonyms: Tbrl1, Trl-1
 
 
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High impact information on Tbrs1

  • Quantitative trait locus mapping identified a major locus on chromosome 19 (Tuberculosis resistance locus-4, Trl-4; logarithm of odds 5.6), which regulated pulmonary replication of M. tuberculosis and accounted for 25% of the phenotypic variance [1].
  • QTL analysis identified two significant linkages on the distal portion of chromosome 1 (Trl-1, LOD, 4.80) and on the proximal portion of chromosome 7 (Trl-3, LOD, 4.66) that each account for approximately 21% of the phenotypic variance [2].

References

  1. Susceptibility to tuberculosis: a locus on mouse chromosome 19 (Trl-4) regulates Mycobacterium tuberculosis replication in the lungs. Mitsos, L.M., Cardon, L.R., Ryan, L., LaCourse, R., North, R.J., Gros, P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice. Mitsos, L.M., Cardon, L.R., Fortin, A., Ryan, L., LaCourse, R., North, R.J., Gros, P. Genes Immun. (2000) [Pubmed]
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