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Gene Review:

Prdt1 - prion disease incubation time 1

Mus musculus

Lloyd, S.E. et al., Engelstein, R. et al.

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High impact information on Prdt1

Inhibition of P53-related apoptosis had no effect on PrP(Sc) accumulation and prion disease incubation time [1].
The major determinant of prion disease incubation time in mice is thought to be the amino acid sequence of the prion protein [2].

References

Inhibition of P53-related apoptosis had no effect on PrP(Sc) accumulation and prion disease incubation time. Engelstein, R., Grigoriadis, N., Greig, N.H., Ovadia, H., Gabizon, R. Neurobiol. Dis. (2005) [Pubmed]
Identification and characterization of a novel mouse prion gene allele. Lloyd, S.E., Thompson, S.R., Beck, J.A., Linehan, J.M., Wadsworth, J.D., Brandner, S., Collinge, J., Fisher, E.M. Mamm. Genome (2004) [Pubmed]

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