Gene Review:
Trp53 - transformation related protein 53
Mus musculus
Synonyms:
Cellular tumor antigen p53, P53, Tp53, Tumor suppressor p53, bbl, ...
Grace Vangeison,
Pin,
Fedorov,
Kawarabayashi,
Gimotty,
Katherine M. Lelli,
David A. Rempe,
French,
Christy,
Reilly,
Makifuchi,
Hulla,
Ohyagi,
Checler,
Chernigovskaya,
Tsuruta,
Iwaki,
Howard J. Federoff,
Finegold,
Tuveson,
Mitin,
Grochow,
Kachatrian,
Willis,
Munroe,
Murai,
Yamova,
Zhu,
Olson,
Randall S. Johnson,
Tsang,
Granville,
Tuskan,
Jacks,
Yamada,
Ikezoe,
Taniwaki,
Chui,
Jacks,
Kira,
Konieczny,
Grompe,
Torimaru,
Ledger,
Taranukhin,
Dunnick,
Miyoshi,
Shoji,
Tabira,
Gopinathan,
Hruban,
Kikuchi,
Takeda,
Akkari,
Asahara,
Sakae,
Smith,
Taparowsky,
Furuya,
Loisel,
Bronson,
Houghtaling,
Glazova,
- Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Liu, G., Parant, J.M., Lang, G., Chau, P., Chavez-Reyes, A., El-Naggar, A.K., Multani, A., Chang, S., Lozano, G. Nat. Genet. (2004)
- An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Hemann, M.T., Fridman, J.S., Zilfou, J.T., Hernando, E., Paddison, P.J., Cordon-Cardo, C., Hannon, G.J., Lowe, S.W. Nat. Genet. (2003)
- Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects. Reilly, K.M., Tuskan, R.G., Christy, E., Loisel, D.A., Ledger, J., Bronson, R.T., Smith, C.D., Tsang, S., Munroe, D.J., Jacks, T. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Heterozygosity for p53 (Trp53+/-) accelerates epithelial tumor formation in fanconi anemia complementation group D2 (Fancd2) knockout mice. Houghtaling, S., Granville, L., Akkari, Y., Torimaru, Y., Olson, S., Finegold, M., Grompe, M. Cancer Res. (2005)
- Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma. Tuveson, D.A., Zhu, L., Gopinathan, A., Willis, N.A., Kachatrian, L., Grochow, R., Pin, C.L., Mitin, N.Y., Taparowsky, E.J., Gimotty, P.A., Hruban, R.H., Jacks, T., Konieczny, S.F. Cancer Res. (2006)
- Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice. Shing, D.C., Trubia, M., Marchesi, F., Radaelli, E., Belloni, E., Tapinassi, C., Scanziani, E., Mecucci, C., Crescenzi, B., Lahortiga, I., Odero, M.D., Zardo, G., Gruszka, A., Minucci, S., Di Fiore, P.P., Pelicci, P.G. J. Clin. Invest. (2007)
- An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations. Caulin, C., Nguyen, T., Lang, G.A., Goepfert, T.M., Brinkley, B.R., Cai, W.W., Lozano, G., Roop, D.R. J. Clin. Invest. (2007)
- Ablation of a peptidyl prolyl isomerase Pin1 from p53-null mice accelerated thymic hyperplasia by increasing the level of the intracellular form of Notch1. Takahashi, K., Akiyama, H., Shimazaki, K., Uchida, C., Akiyama-Okunuki, H., Tomita, M., Fukumoto, M., Uchida, T. Oncogene (2007)
- HPV16 E6 confers p53-dependent and p53-independent phenotypes in the epidermis of mice deficient for E6AP. Shai, A., Nguyen, M.L., Wagstaff, J., Jiang, Y.H., Lambert, P.F. Oncogene (2007)
- Apoptogenic effects of black tea on Ehrlich's ascites carcinoma cell. Bhattacharyya, A., Choudhuri, T., Pal, S., Chattopadhyay, S., K Datta, G., Sa, G., Das, T. Carcinogenesis (2003)
- Genetic interaction between expanded murine Hdh alleles and p53 reveal deleterious effects of p53 on Huntington's disease pathogenesis. Ryan, A.B., Zeitlin, S.O., Scrable, H. Neurobiol. Dis. (2006)
- Apoptotic signaling proteins: possible participation in the regulation of vasopressin and catecholamines biosynthesis in the hypothalamus. Chernigovskaya, E.V., Taranukhin, A.G., Glazova, M.V., Yamova, L.A., Fedorov, L.M. Histochem. Cell Biol. (2005)
- Inhibition of poly(ADP-ribose) polymerase activity accelerates T-cell lymphomagenesis in p53 deficient mice. Beneke, R., Möröy, T. Oncogene (2001)
- Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease. Ohyagi, Y., Asahara, H., Chui, D.H., Tsuruta, Y., Sakae, N., Miyoshi, K., Yamada, T., Kikuchi, H., Taniwaki, T., Murai, H., Ikezoe, K., Furuya, H., Kawarabayashi, T., Shoji, M., Checler, F., Iwaki, T., Makifuchi, T., Takeda, K., Kira, J., Tabira, T. FASEB J. (2005)
- PRAK Is Essential for ras-Induced Senescence and Tumor Suppression. Sun, P., Yoshizuka, N., New, L., Moser, B.A., Li, Y., Liao, R., Xie, C., Chen, J., Deng, Q., Yamout, M., Dong, M.Q., Frangou, C.G., Yates, J.R., Wright, P.E., Han, J. Cell (2007)
- NEDD4-1 Is a Proto-Oncogenic Ubiquitin Ligase for PTEN. Wang, X., Trotman, L.C., Koppie, T., Alimonti, A., Chen, Z., Gao, Z., Wang, J., Erdjument-Bromage, H., Tempst, P., Cordon-Cardo, C., Pandolfi, P.P., Jiang, X. Cell (2007)
- Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Dews, M., Homayouni, A., Yu, D., Murphy, D., Sevignani, C., Wentzel, E., Furth, E.E., Lee, W.M., Enders, G.H., Mendell, J.T., Thomas-Tikhonenko, A. Nat. Genet. (2006)
- Modeling the Therapeutic Efficacy of p53 Restoration in Tumors. Martins, C.P., Brown-Swigart, L., Evan, G.I. Cell (2006)
- Deletion of DDB1 in Mouse Brain and Lens Leads to p53-Dependent Elimination of Proliferating Cells. Cang, Y., Zhang, J., Nicholas, S.A., Bastien, J., Li, B., Zhou, P., Goff, S.P. Cell (2006)
- Chromosome 11 allelotypes reflect a mechanism of chemical carcinogenesis in heterozygous p53-deficient mice. Hulla, J.E., French, J.E., Dunnick, J.K. Carcinogenesis (2001)
- Low levels of p53 are associated with resistance to tetrachlorodibenzo-p-dioxin toxicity in DBA/2 mice. Yang, A.L., Smith, A.G., Akhtar, R., Clothier, B., Robinson, S., MacFarlane, M., Festing, M.F. Pharmacogenetics (1999)
- Cytogenetic findings, Trp53 mutations, and hormone responsiveness in a medroxyprogesterone acetate induced murine breast cancer model. Fabris, V.T., Benavides, F., Conti, C., Merani, S., Lanari, C. Cancer Genet. Cytogenet. (2005)
- Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers. Halberg, R.B., Katzung, D.S., Hoff, P.D., Moser, A.R., Cole, C.E., Lubet, R.A., Donehower, L.A., Jacoby, R.F., Dove, W.F. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Distinct Effects of Annexin A7 and p53 on Arachidonate Lipoxygenation in Prostate Cancer Cells Involve 5-Lipoxygenase Transcription. Torosyan, Y., Dobi, A., Naga, S., Mezhevaya, K., Glasman, M., Norris, C., Jiang, G., Mueller, G., Pollard, H., Srivastava, M. Cancer Res. (2006)
- The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality. Johnson, T.M., Hammond, E.M., Giaccia, A., Attardi, L.D. Nat. Genet. (2005)
- Isolation and mapping to 17p12-13 of the human homologous of the murine growth arrest specific Gas-3 gene. Martinotti, A., Cariani, C.T., Melani, C., Sozzi, G., Spurr, N.K., Pierotti, M.A., Colombo, M.P. Hum. Mol. Genet. (1992)
- Loss of heterozygosity occurs via mitotic recombination in Trp53+/- mice and associates with mammary tumor susceptibility of the BALB/c strain. Blackburn, A.C., McLary, S.C., Naeem, R., Luszcz, J., Stockton, D.W., Donehower, L.A., Mohammed, M., Mailhes, J.B., Soferr, T., Naber, S.P., Otis, C.N., Jerry, D.J. Cancer Res. (2004)
- Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Jackson-Grusby, L., Beard, C., Possemato, R., Tudor, M., Fambrough, D., Csankovszki, G., Dausman, J., Lee, P., Wilson, C., Lander, E., Jaenisch, R. Nat. Genet. (2001)
- Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Xu, X., Qiao, W., Linke, S.P., Cao, L., Li, W.M., Furth, P.A., Harris, C.C., Deng, C.X. Nat. Genet. (2001)
- Snm1-deficient mice exhibit accelerated tumorigenesis and susceptibility to infection. Ahkter, S., Richie, C.T., Zhang, N., Behringer, R.R., Zhu, C., Legerski, R.J. Mol. Cell. Biol. (2005)
- Epithelial cell cycling predicts p53 responsiveness to gamma-irradiation during post-natal mammary gland development. Minter, L.M., Dickinson, E.S., Naber, S.P., Jerry, D.J. Development (2002)
- Deficiency of Trp53 rescues the male fertility defects of Kit(W-v) mice but has no effect on the survival of melanocytes and mast cells. Jordan, S.A., Speed, R.M., Bernex, F., Jackson, I.J. Dev. Biol. (1999)
- Age-related mutation accumulation at a lacZ reporter locus in normal and tumor tissues of Trp53-deficient mice. Giese, H., Snyder, W.K., van Oostrom, C., van Steeg, H., Dollé, M.E., Vijg, J. Mutat. Res. (2002)
- Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1. Wagner, A.J., Kokontis, J.M., Hay, N. Genes Dev. (1994)
- p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes. Smith, M.L., Ford, J.M., Hollander, M.C., Bortnick, R.A., Amundson, S.A., Seo, Y.R., Deng, C.X., Hanawalt, P.C., Fornace, A.J. Mol. Cell. Biol. (2000)
- Impaired hepatocyte survival and liver regeneration in Atm-deficient mice. Lu, S., Shen, K.C., Wang, Y., Brooks, S.C., Wang, Y.A. Hum. Mol. Genet. (2005)
- Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress. Okoshi, R., Ozaki, T., Yamamoto, H., Ando, K., Koida, N., Ono, S., Koda, T., Kamijo, T., Nakagawara, A., Kizaki, H. J. Biol. Chem. (2008)
- Control of cell cycle progression by c-Jun is p53 dependent. Schreiber, M., Kolbus, A., Piu, F., Szabowski, A., Möhle-Steinlein, U., Tian, J., Karin, M., Angel, P., Wagner, E.F. Genes Dev. (1999)
- ARF mutation accelerates pituitary tumor development in Rb+/- mice. Tsai, K.Y., MacPherson, D., Rubinson, D.A., Nikitin, A.Y., Bronson, R., Mercer, K.L., Crowley, D., Jacks, T. Proc. Natl. Acad. Sci. U.S.A. (2002)
- The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2. Jones, S.N., Sands, A.T., Hancock, A.R., Vogel, H., Donehower, L.A., Linke, S.P., Wahl, G.M., Bradley, A. Proc. Natl. Acad. Sci. U.S.A. (1996)
- BALB/c alleles for Prkdc and Cdkn2a interact to modify tumor susceptibility in Trp53+/- mice. Blackburn, A.C., Brown, J.S., Naber, S.P., Otis, C.N., Wood, J.T., Jerry, D.J. Cancer Res. (2003)
- UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin-kinase inhibitor in a p53-independent manner. Haapajärvi, T., Kivinen, L., Heiskanen, A., des Bordes, C., Datto, M.B., Wang, X.F., Laiho, M. Exp. Cell Res. (1999)
- A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells. Yu, J., Baron, V., Mercola, D., Mustelin, T., Adamson, E.D. Cell Death Differ. (2007)
- Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis. Wang, W.H., Hullinger, R.L., Andrisani, O.M. J. Biol. Chem. (2008)
- Induction and bypass of p53 during productive infection by polyomavirus. Dey, D., Dahl, J., Cho, S., Benjamin, T.L. J. Virol. (2002)
- p53 induction, cell cycle checkpoints, and apoptosis in DNAPK-deficient scid mice. Gurley, K.E., Kemp, C.J. Carcinogenesis (1996)
- Low levels of glutathione peroxidase 1 activity in selenium-deficient mouse liver affect c-Jun N-terminal kinase activation and p53 phosphorylation on Ser-15 in pro-oxidant-induced aponecrosis. Cheng, W.H., Zheng, X., Quimby, F.R., Roneker, C.A., Lei, X.G. Biochem. J. (2003)
- Involvement of poly(ADP-Ribose) polymerase 1 and poly(ADP-Ribosyl)ation in regulation of centrosome function. Kanai, M., Tong, W.M., Sugihara, E., Wang, Z.Q., Fukasawa, K., Miwa, M. Mol. Cell. Biol. (2003)
- Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases. Milne, D.M., Campbell, D.G., Caudwell, F.B., Meek, D.W. J. Biol. Chem. (1994)
- Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Eischen, C.M., Weber, J.D., Roussel, M.F., Sherr, C.J., Cleveland, J.L. Genes Dev. (1999)
- p53-independent functions of the p19(ARF) tumor suppressor. Weber, J.D., Jeffers, J.R., Rehg, J.E., Randle, D.H., Lozano, G., Roussel, M.F., Sherr, C.J., Zambetti, G.P. Genes Dev. (2000)
- p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes. Bogue, M.A., Zhu, C., Aguilar-Cordova, E., Donehower, L.A., Roth, D.B. Genes Dev. (1996)
- c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity. Stepniak, E., Ricci, R., Eferl, R., Sumara, G., Sumara, I., Rath, M., Hui, L., Wagner, E.F. Genes Dev. (2006)
- E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos. Ziebold, U., Reza, T., Caron, A., Lees, J.A. Genes Dev. (2001)
- Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis. Coles, A.H., Liang, H., Zhu, Z., Marfella, C.G., Kang, J., Imbalzano, A.N., Jones, S.N. Cancer Res. (2007)
- p73 suppresses polyploidy and aneuploidy in the absence of functional p53. Talos, F., Nemajerova, A., Flores, E.R., Petrenko, O., Moll, U.M. Mol. Cell (2007)
- In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute. Michalak, E.M., Villunger, A., Adams, J.M., Strasser, A. Cell Death Differ. (2008)
- Nucleophosmin blocks mitochondrial localization of p53 and apoptosis. Dhar, S.K., St Clair, D.K. J. Biol. Chem. (2009)
- Partial rescue of the prophase I defects of Atm-deficient mice by p53 and p21 null alleles. Barlow, C., Liyanage, M., Moens, P.B., Deng, C.X., Ried, T., Wynshaw-Boris, A. Nat. Genet. (1997)
- Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. Ries, S., Biederer, C., Woods, D., Shifman, O., Shirasawa, S., Sasazuki, T., McMahon, M., Oren, M., McCormick, F. Cell (2000)
- Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation. Hakem, R., de la Pompa, J.L., Elia, A., Potter, J., Mak, T.W. Nat. Genet. (1997)
- Three distinct signalling responses by murine fibroblasts to genotoxic stress. Liu, Z.G., Baskaran, R., Lea-Chou, E.T., Wood, L.D., Chen, Y., Karin, M., Wang, J.Y. Nature (1996)
- Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Marino, S., Vooijs, M., van Der Gulden, H., Jonkers, J., Berns, A. Genes Dev. (2000)
- Essential postmitochondrial function of p53 uncovered in DNA damage-induced apoptosis in neurons. Vaughn, A.E., Deshmukh, M. Cell Death Differ. (2007)
- A novel role for IGF-1R in p53-mediated apoptosis through translational modulation of the p53-Mdm2 feedback loop. Xiong, L., Kou, F., Yang, Y., Wu, J. J. Cell Biol. (2007)
- In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1alpha function regardless of the presence of DNA damage. Rempe, D.A., Lelli, K.M., Vangeison, G., Johnson, R.S., Federoff, H.J. J. Biol. Chem. (2007)
- MSL2 promotes Mdm2-independent cytoplasmic localization of p53. Kruse, J.P., Gu, W. J. Biol. Chem. (2009)
- Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. TeKippe, M., Harrison, D.E., Chen, J. Exp. Hematol. (2003)
- Organ-specific gene expressions in C57BL/6 mice after exposure to low-dose radiation. Lee, W.J., Majumder, Z.R., Jeoung, D.I., Lee, H.J., Kim, S.H., Bae, S., Lee, Y.S. Radiat. Res. (2006)
- p53 heterozygosity alters the mRNA expression of p53 target genes in the bone marrow in response to inhaled benzene. Boley, S.E., Wong, V.A., French, J.E., Recio, L. Toxicol. Sci. (2002)