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Gene Review:

Pou2f2 - POU class 2 homeobox 2

Rattus norvegicus

Synonyms: 2-Oct, Oct2

Dees, W.L. et al.

Dees, Srivastava, Hiney,

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High impact information on Pou2f2

In another experiment, we determined whether ALC (3 g/kg) could block IGF-1-induced Oct 2 gene expression [1].

Associations of Pou2f2 with chemical compounds

Furthermore, as alcohol (ALC) blocks IGF-1-induced LHRH and LH release acutely, we aimed to determine if it could affect the ability of IGF-1 to stimulate Oct 2 gene expression [1].

Regulatory relationships of Pou2f2

CONCLUSIONS: IGF-1 induced Oct 2 genes prior to the normal increase during the late juvenile period, indicating this IGF- 1 induction may be an early event in the activation of the LHRH secretory pathway [1].

References

Alcohol alters insulin-like growth factor-1 activated oct 2 POU domain gene expression in the immature female hypothalamus. Dees, W.L., Srivastava, V.K., Hiney, J.K. J. Stud. Alcohol (2005) [Pubmed]

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POU2F2	Macaca mulatta
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pou2f2	Xenopus (Silurana) tropicalis

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