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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

T2dm2  -  type 2 diabetes mellitus 2

Mus musculus

Synonyms: insulin level locus 2, t2dm2
 
 
 
 
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High impact information on T2dm2

  • This was the only gene in the 1339A strain for which we detected amino acid substitutions and expression level differences between mice carrying B6 and BTBR alleles of this insert, thereby identifying variation within the Sorcs1 gene as underlying the phenotype associated with the T2dm2 locus [1].
  • Introgression of a 7-Mb segment of the B6 chromosome 19 into the BTBR background (strain 1339A) replicated the reduced insulin linked to T2dm2 [1].
  • We used subcongenic strains derived from 1339A to localize the T2dm2 quantitative trait locus (QTL) to a 242-kb segment comprising the promoter, first exon and most of the first intron of the Sorcs1 gene [1].
  • We previously mapped the type 2 diabetes mellitus-2 locus (T2dm2), which affects fasting insulin levels, to distal chromosome 19 in a leptin-deficient obese F2 intercross derived from C57BL/6 (B6) and BTBR T+ tf/J (BTBR) mice [1].

References

  1. Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus. Clee, S.M., Yandell, B.S., Schueler, K.M., Rabaglia, M.E., Richards, O.C., Raines, S.M., Kabara, E.A., Klass, D.M., Mui, E.T., Stapleton, D.S., Gray-Keller, M.P., Young, M.B., Stoehr, J.P., Lan, H., Boronenkov, I., Raess, P.W., Flowers, M.T., Attie, A.D. Nat. Genet. (2006) [Pubmed]
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