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Gene Review

ZFYVE27  -  zinc finger, FYVE domain containing 27

Homo sapiens

Synonyms: FLJ32919, PROTRUDIN, Protrudin, SPG33, Zinc finger FYVE domain-containing protein 27
 
 
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Disease relevance of ZFYVE27

 

High impact information on ZFYVE27

  • We postulate that this specific mutation in ZFYVE27 affects neuronal intracellular trafficking in the corticospinal tract, which is consistent with the pathology of HSP [1].

References

  1. ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia. Mannan, A.U., Krawen, P., Sauter, S.M., Boehm, J., Chronowska, A., Paulus, W., Neesen, J., Engel, W. Am. J. Hum. Genet. (2006) [Pubmed]
 
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