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Gene Review:

alaS - alanyl-tRNA synthetase

Enterococcus faecalis V583

Bouhss, A. et al., Bouhss, A. et al.

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Disease relevance of alaS

The UDP-MurNAc-pentapeptide:L-alanine ligase and alanyl-tRNA synthetase genes from Enterococcus faecalis were identified, cloned, and overexpressed in Escherichia coli [1].

High impact information on alaS

The pathway involved alanyl-tRNA synthetase and two ligases, BppA1 and BppA2, that specifically transfer alanine from Ala-tRNA to the first and second positions of the side chain, respectively [2].

References

Identification of the UDP-MurNAc-pentapeptide:L-alanine ligase for synthesis of branched peptidoglycan precursors in Enterococcus faecalis. Bouhss, A., Josseaume, N., Allanic, D., Crouvoisier, M., Gutmann, L., Mainardi, J.L., Mengin-Lecreulx, D., van Heijenoort, J., Arthur, M. J. Bacteriol. (2001) [Pubmed]
Synthesis of the L-alanyl-L-alanine cross-bridge of Enterococcus faecalis peptidoglycan. Bouhss, A., Josseaume, N., Severin, A., Tabei, K., Hugonnet, J.E., Shlaes, D., Mengin-Lecreulx, D., Van Heijenoort, J., Arthur, M. J. Biol. Chem. (2002) [Pubmed]

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