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Gene Review:

vanW - vancomycin B-type resistance protein VanW

Enterococcus faecalis V583

McGregor, K.F. et al., Evers, S. et al.

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High impact information on vanW

Restriction fragment length polymorphism analysis of a 5,180-bp vanS(B)-vanX(B) long-PCR fragment of the vanB cluster showed the loss of HaeII restriction sites in vanS(B), vanW, and vanX(B) in strains containing a vanB2 ligase gene [1].
Upstream from the structural genes for these proteins were the vanY(B) gene encoding a D,D-carboxypeptidase and an open reading frame vanW with an unknown function [2].

References

Identification and characterization of vanB2 glycopeptide resistance elements in enterococci isolated in Scotland. McGregor, K.F., Young, H.K. Antimicrob. Agents Chemother. (2000) [Pubmed]
Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583. Evers, S., Courvalin, P. J. Bacteriol. (1996) [Pubmed]

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