Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

IKBIP - IKBKB interacting protein

Homo sapiens

Synonyms: FLJ31051, I kappa-B kinase-interacting protein, IKBKB-interacting protein, IKIP, IKK-interacting protein, ...

Sebald, A. et al., Hofer-Warbinek, R. et al.

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High impact information on IKIP

Moreover, IKIP promotes apoptosis when transfected into endothelial cells [1].
Various experimental approaches revealed that costimulation-induced IKK alpha/beta activation loop phosphorylation is independent from IKK beta-mediated transautophosphorylation, but rather involves phosphorylation by the IKK-interacting protein NIK and its upstream activator COT [2].

References

A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53. Hofer-Warbinek, R., Schmid, J.A., Mayer, H., Winsauer, G., Orel, L., Mueller, B., Wiesner, C.h., Binder, B.R., de Martin, R. Cell Death Differ. (2004) [Pubmed]
T cell receptor-induced lipid raft recruitment of the I kappa B kinase complex is necessary and sufficient for NF-kappa B activation occurring in the cytosol. Sebald, A., Mattioli, I., Schmitz, M.L. Eur. J. Immunol. (2005) [Pubmed]

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IKBIP	Canis lupus familiaris
IKBIP	Gallus gallus
IKBIP	Macaca mulatta
Ikbip	Mus musculus
IKBIP	Pan troglodytes
Ikbip	Rattus norvegicus

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