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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

hfq  -  RNA-binding protein Hfq

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

 
 
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High impact information on hfq

  • Further investigation demonstrated that sigma(E) augments sigma(S) levels during stationary phase via enhanced expression of sigma(H) and the RNA-binding protein Hfq, leading to increased expression of sigma(S)-dependent genes and enhanced resistance to oxidative stress [1].
  • Insertions in several other genes, including such highly pleiotropic mutants as rpoS, polA, and hfq, were isolated with the same phenotypic screen, but they do not affect the beta-galactosidase activity of HemA-LacZ [2].

References

  1. Alternative sigma factor interactions in Salmonella: sigma and sigma promote antioxidant defences by enhancing sigma levels. Bang, I.S., Frye, J.G., McClelland, M., Velayudhan, J., Fang, F.C. Mol. Microbiol. (2005) [Pubmed]
  2. Stabilization of a HemA-LacZ hybrid protein against proteolysis during carbon starvation in atp mutants of Salmonella typhimurium. Archer, C.D., Jin, J., Elliott, T. J. Bacteriol. (1996) [Pubmed]
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