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Gene Review:

srnB - srnB

Escherichia coli K-12

Akimoto, S. et al., Nielsen, A.K. et al.

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High impact information on srnB

The gene systems srnB of plasmid F and pnd of plasmid R483 were discovered because of their induction by rifampicin [1].
Transcriptional regulation of F plasmid gene srnB: rifampicin-promoted in vitro readthrough of a terminator in the leader region [2].

Biological context of srnB

srnB is an F-plasmid encoded gene, otherwise silent, whose expression is induced by added rifampicin, leading to the release of cellular Mg2+ and degradation of stable RNA [2].

References

The rifampicin-inducible genes srnB from F and pnd from R483 are regulated by antisense RNAs and mediate plasmid maintenance by killing of plasmid-free segregants. Nielsen, A.K., Thorsted, P., Thisted, T., Wagner, E.G., Gerdes, K. Mol. Microbiol. (1991) [Pubmed]
Transcriptional regulation of F plasmid gene srnB: rifampicin-promoted in vitro readthrough of a terminator in the leader region. Akimoto, S., Sakikawa, T., Ono, K., Ono, T., Ohnishi, Y. Mol. Microbiol. (1989) [Pubmed]

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