Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

WFDC12 - WAP four-disulfide core domain 12

Homo sapiens

Synonyms: C20orf122, SWAM2, UNQ544/PRO844, WAP four-disulfide core domain protein 12, WAP2, ...

Goto, M. et al., Hagiwara, K. et al.

Hagiwara, Kikuchi, Endo, Huqun, Usui, Takahashi, Shibata, Kusakabe, Xin, Hoshi, Miki, Inooka, Tokue, Nukiwa,

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Disease relevance of WFDC12

SWAM1 and SWAM2 inhibit the growth of both Escherichia coli and Staphylococcus aureus at a IC(90) (concentration that achieves 90% inhibition) of 10 microM [1].

High impact information on WFDC12

PGC-1 mRNA level in Epi muscle in rats that swam 2 h a day for 3 and 7 days increased dramatically by 154% and 163%, respectively, compared to the non-exercised control group [2].

References

Mouse SWAM1 and SWAM2 are antibacterial proteins composed of a single whey acidic protein motif. Hagiwara, K., Kikuchi, T., Endo, Y., Huqun, n.u.l.l., Usui, K., Takahashi, M., Shibata, N., Kusakabe, T., Xin, H., Hoshi, S., Miki, M., Inooka, N., Tokue, Y., Nukiwa, T. J. Immunol. (2003) [Pubmed]
cDNA Cloning and mRNA analysis of PGC-1 in epitrochlearis muscle in swimming-exercised rats. Goto, M., Terada, S., Kato, M., Katoh, M., Yokozeki, T., Tabata, I., Shimokawa, T. Biochem. Biophys. Res. Commun. (2000) [Pubmed]

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