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Gene Review:

CHODL - chondrolectin

Homo sapiens

Synonyms: C21orf68, Chondrolectin, FLJ12627, MT75, PRED12, ...

Weng, L. et al., Masuda, K. et al.

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Disease relevance of CHODL

Treatment of lung cancer cells with siRNAs against CHODL suppressed growth of the cancer cells [1].

High impact information on CHODL

Of all variants, the alternative exon E-splicing isoforms (CHODLf Delta E/CHODL Delta E) are expressed exclusively in the T lymphocyte lineage and are regulated during T lymphopoiesis [2].
The P2 promoter gives rise to at least three additional alternatively spliced isoforms, designated as CHODLf, CHODLf Delta E, and CHODL Delta E [2].

References

Chondrolectin is a novel diagnostic biomarker and a therapeutic target for lung cancer. Masuda, K., Takano, A., Oshita, H., Akiyama, H., Tsuchiya, E., Kohno, N., Nakamura, Y., Daigo, Y. Clin. Cancer Res. (2011) [Pubmed]
A novel alternative spliced chondrolectin isoform lacking the transmembrane domain is expressed during T cell maturation. Weng, L., Van Bockstaele, D.R., Wauters, J., Van Marck, E., Plum, J., Berneman, Z.N., Merregaert, J. J. Biol. Chem. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

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