Disease relevance of Lymphopoiesis

• Given its ability to physically interact with Hrx, a developmental regulator subject to translocation-induced mutations in B cell precursor leukemias, the current studies were undertaken to assess the effects of Sbf1 on lymphopoiesis [1].
• Additionally, ectopic activation of the tal-1 gene during T lymphopoiesis occurs in numerous cases of human T-cell acute lymphoblastic leukemia [2].
• Most data suggest that malignant transformation in chronic myelogenous leukemia (CML) occurs in hematopoietic stem cell that is the progenitor of myelopoiesis and of B but not T lymphopoiesis [3].
• Estrogen deficiency stimulates both osteoclastic bone resorption and pre-B lymphopoiesis, the interrelationships between which remain unknown [4].
• CD44 is a widely expressed cell adhesion molecule that has been implicated in a variety of biological processes including lymphopoiesis, angiogenesis, wound healing, leukocyte extravasation at inflammatory sites, and tumor metastasis [5].

High impact information on Lymphopoiesis

• Proteins expressed from productively rearranged H and L chain gene loci have been implied in the regulation of Ig gene rearrangements during B lymphopoiesis [6].
• Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice [7].
• Here we report that this process is regulated by the alpha-chain of the receptor for interleukin-7, a cytokine that stimulates B-cell lymphopoiesis [8].
• As the protein encoded by the bcl-2 gene can inhibit cell death, we tested whether lymphopoiesis could be rescued in scid mice by crossing in a bcl-2 transgene [9].
• A potent inhibitor of B lymphopoiesis [transforming growth factor-beta (TGF-beta)] was used to explore the mechanisms in the activation of kappa transcription by LPS and by interferon-gamma (IFN-gamma) [10].

Chemical compound and disease context of Lymphopoiesis

• The failure to sustain lymphopoiesis by the potential lymphoid sites following cyclophosphamide treatment and the associated immunological insufficiency resulted in the fatal wasting disease [11].
• Prophylactic clarithromycin to treat mycobacterium avium in HIV patients receiving zidovudine may significantly increase mortality by suppressing lymphopoiesis and hematopoiesis [12].

Biological context of Lymphopoiesis

• Ikaros is a unique regulator of lymphopoiesis that associates with pericentromeric heterochromatin and has been implicated in heritable gene inactivation [13].
• Here we present a detailed analysis of the B-cell phenotype of Pax5 mutant mice that revealed a differential dependency of fetal and adult B lymphopoiesis on this transcriptional regulator [14].
• Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene [15].
• Lineage association is known to exist between p53 expression and normal lymphopoiesis, but not myelopoiesis [16].
• In contrast to earlier reports, these data exclude an essential role for beta-catenin during hematopoiesis and lymphopoiesis [17].

Anatomical context of Lymphopoiesis

• T lymphopoiesis is rescued when Ikkbeta-/- stem cells are cotransferred with wt bone marrow, suggesting that IKKbeta may mediate its lymphopoietic function via extrinsic factors [18].
• To assess the importance of Btk function in murine lymphopoiesis, we generated multiple embryonic stem cell clones bearing a targeted disruption of the btk gene and examined their potential to produce lymphocytes in both C57BL/6 and RAG2-/- host chimeric animals [19].
• Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells [20].
• Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice [21].
• Defective lymphopoiesis in bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. I. Analysis of development of prothymocytes, early B lineage cells, and terminal deoxynucleotidyl transferase-positive cells [22].

Associations of Lymphopoiesis with chemical compounds

• Estrogen is a negative regulator of lymphopoiesis and provides an experimental tool for probing relationships between lymphocyte precursors and stem cells [23].
• Thus, IL-7 receptor signaling is a participant in the formation of the transcription factor network during B lymphopoiesis by up-regulating EBF, allowing stage transition from the pre-pro-B to further maturational stages [24].
• Increased B lymphopoiesis in genetically sex steroid-deficient hypogonadal (hpg) mice [25].
• Control of lymphopoiesis by p50csk, a regulatory protein tyrosine kinase [26].
• Aware of the defective lymphopoiesis associated with adenosine deaminase and purine nucleoside phosphorylase deficiencies, we hypothesized that abnormal purine or pyrimidine metabolism might be present in these dogs [27].

Gene context of Lymphopoiesis

• Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus [14].
• Notch1 expression in early lymphopoiesis influences B versus T lineage determination [28].
• Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis [29].
• Here we show that Bcl11a is essential for postnatal development and normal lymphopoiesis [30].
• Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A [31].

Analytical, diagnostic and therapeutic context of Lymphopoiesis

• We utilized gene targeting by homologous recombination to define the role that MEF, a transcriptional activating member of the ETS family of transcription factors, plays in lymphopoiesis [32].
• Ligation of CD38 suppresses human B lymphopoiesis [33].
• Reduced expression of vascular cell adhesion molecule-1 on bone marrow stromal cells isolated from marrow transplant recipients correlates with a reduced capacity to support human B lymphopoiesis in vitro [34].
• Finally, human B lymphopoiesis was also sensitive to adiponectin in stromal cell cocultures [35].
• Mechanisms of chemoprevention by dietary dehydroisoandrosterone. Inhibition of lymphopoiesis [36].

References