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Gene Review

STK35  -  serine/threonine kinase 35

Homo sapiens

Synonyms: CLIK-1, CLIK1, CLP-36-interacting kinase 1, PDIK1, PDLIM1-interacting kinase 1, ...

STK35 also known as STK35L1 [1] or CLIK1 [2] is a member of the NKF4 (New Kinase Family 4) Ser/Thr kinases (STK) family and classified in group “Other” in the human kinome [3].

STK35 has also been named as Clik1 (CLP36 Interacting Kinase 1) based on a study that showed an association of STK35 with CLP36 after overexpression of both proteins in osteosarcoma cells [2]. Clik1 gene described by Vallenius et al code for a protein of 501 amino acids. Later, Goyal et al found that coding sequence of the STK35 gene is incomplete. The newly identified sequence of the STK35 gene codes for a protein of 534 amino acids with a N-terminal elongation of 133 amino acids. It has been designated as STK35L1 [1].



High impact information on STK35



  1. Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates. Goyal, P., Behring, A., Kumar, A., Siess, W. PLoS. One. (2009) [Pubmed]
  2. Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein. Vallenius, T., Mäkelä, T.P. J. Cell. Sci. (2002) [Pubmed]
  3. The protein kinase complement of the human genome. Manning, G., Whyte, D.B., Martinez, R., Hunter, T., Sudarsanam, S. Science. (2002) [Pubmed]
  4. STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells. Goyal, P., Behring, A., Kumar, A., Siess, W. PLoS. One. (2011) [Pubmed]
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