STK35 also known as STK35L1 [1] or CLIK1 [2] is a member of the NKF4 (New Kinase Family 4) Ser/Thr kinases (STK) family and classified in group “Other” in the human kinome [3].

STK35 has also been named as Clik1 (CLP36 Interacting Kinase 1) based on a study that showed an association of STK35 with CLP36 after overexpression of both proteins in osteosarcoma cells [2]. Clik1 gene described by Vallenius et al code for a protein of 501 amino acids. Later, Goyal et al found that coding sequence of the STK35 gene is incomplete. The newly identified sequence of the STK35 gene codes for a protein of 534 amino acids with a N-terminal elongation of 133 amino acids. It has been designated as STK35L1 [1].

High impact information on STK35

• STK35L1 was mainly localized in the nucleus and nucleolus [1].
• Nuclear actin was identified as a novel binding partner of STK35L1 [4].
• Interestingly, the association with CLP-36 led to relocalization of the otherwise nuclear Clik1 kinase to actin stress fibers, where it disrupted the periodic staining pattern of CLP-36 [2].
• Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein [2].

References