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Gene Review:

malA - alpha-glucosidase

Sulfolobus solfataricus P2

Haseltine, C. et al., Hoang, V. et al.

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High impact information on malA

Expression of a promoter fusion between lacS and the car-independent malA promoter integrated either at amyA or at the natural lacS locus was insensitive to the allelic state of car [1].
The specific activities of three enzymes, an alpha-glucosidase (malA), a beta-glycosidase (lacS), and an alpha-amylase, were reduced 4-, 20-, and 10-fold, respectively, in response to the addition of supplementary carbon sources to a minimal sucrose medium [2].

Analytical, diagnostic and therapeutic context of malA

Northern blot analysis of malA and lacS mRNAs revealed that changes in enzyme abundance arose primarily from reductions in transcript concentrations [2].

References

The role of cis-acting sequences governing catabolite repression control of lacS expression in the archaeon Sulfolobus solfataricus. Hoang, V., Bini, E., Dixit, V., Drozda, M., Blum, P. Genetics (2004) [Pubmed]
Coordinate transcriptional control in the hyperthermophilic archaeon Sulfolobus solfataricus. Haseltine, C., Montalvo-Rodriguez, R., Bini, E., Carl, A., Blum, P. J. Bacteriol. (1999) [Pubmed]

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