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MeSH Review

Blotting, Northern

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Disease relevance of Blotting, Northern


Psychiatry related information on Blotting, Northern


High impact information on Blotting, Northern

  • Northern-blot analysis demonstrated ATP6N1B expression in kidney but not other main organs [11].
  • A fourth family showed undetectable amounts of STFB mRNA by northern blot analysis in an affected individual [12].
  • We used Northern blot analysis and ribonuclease protection assays to measure the expression of messenger RNA (mRNA) of bone morphogenetic proteins 1 to 7 and immunohistochemical analysis to examine protein expression [13].
  • Northern blot analyses show that HERG is strongly expressed in the heart [14].
  • Northern blot analyses demonstrate a smaller than normal Epb4.2 transcript in affected pallid tissues, such as kidney and skin [15].

Chemical compound and disease context of Blotting, Northern


Biological context of Blotting, Northern

  • Northern blot analysis and nucleotide sequences of the two clones suggest that an identical species of the thromboxane A2 receptor is present in platelets and vascular tissues [21].
  • Analysis of a mek1::lacZ fusion gene and Northern blot hybridization demonstrate that the MEK1 transcript is present only in meiosis [22].
  • Multiple species of TL mRNA were detected in TL+ cells by Northern blot analysis with pTL1, and different Tla haplotypes could be distinguished on the basis of characteristic patterns of TL mRNA [23].
  • To study whether regulatory mechanisms are affected by this polymorphism, we analyzed the TNF-alpha/TNF-beta production of phytohemagglutinin-stimulated peripheral blood mononuclear cells of individuals homozygous for the TNF-beta NcoI RFLP by ELISA and concomitant Northern blot analysis [24].
  • In all three models, the classical morphological and biochemical features of PCD observed did not correlate with an increase, but with either a marked decrease or an absence of clusterin gene expression as assessed by Northern blot analysis [25].

Anatomical context of Blotting, Northern


Associations of Blotting, Northern with chemical compounds

  • Northern blot hybridization demonstrated an existence of two separate mRNA components, one for the COOH-terminal region and the other for the NH2-terminal region [31].
  • Northern blots indicated that the gene is expressed in wild-type endosperm but not in leaf tissues or in endosperms homozygous for a mutant allele of the O2 gene [32].
  • Detection of mRNA for rat CD8 alpha chain by Northern blot closely paralleled the cell surface expression of CD8 alpha antigen, indicating that dexamethasone and IL-4 had opposing effects on mRNA levels [33].
  • Northern blot analyses indicated that one I-A-, I-E+ tumor strongly expressed A alpha, E alpha, and E beta mRNAs but possessed only a weak expression of A beta mRNA [34].
  • This level of expression was also evident on Northern blots and likely confers the high capacity of this glucose transport system [35].

Gene context of Blotting, Northern


Analytical, diagnostic and therapeutic context of Blotting, Northern


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  3. mRNA expression of transforming growth factor alpha in human breast carcinomas and its activity in effusions of breast cancer patients. Ciardiello, F., Kim, N., Liscia, D.S., Bianco, C., Lidereau, R., Merlo, G., Callahan, R., Greiner, J., Szpak, C., Kidwell, W. J. Natl. Cancer Inst. (1989) [Pubmed]
  4. Expression and release of interleukin-1 by different human melanoma cell lines. Köck, A., Schwarz, T., Urbanski, A., Peng, Z., Vetterlein, M., Micksche, M., Ansel, J.C., Kung, H.F., Luger, T.A. J. Natl. Cancer Inst. (1989) [Pubmed]
  5. Endothelin-3 induces hypertrophy of cardiomyocytes by the endogenous endothelin-1-mediated mechanism. Tamamori, M., Ito, H., Adachi, S., Akimoto, H., Marumo, F., Hiroe, M. J. Clin. Invest. (1996) [Pubmed]
  6. On the stability of messenger RNA and ribosomal RNA in the brains of control human subjects and patients with Alzheimer's disease. Ross, B.M., Knowler, J.T., McCulloch, J. J. Neurochem. (1992) [Pubmed]
  7. Expression of the SOX10 gene during human development. Bondurand, N., Kobetz, A., Pingault, V., Lemort, N., Encha-Razavi, F., Couly, G., Goerich, D.E., Wegner, M., Abitbol, M., Goossens, M. FEBS Lett. (1998) [Pubmed]
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  9. Expression of Egr-1 in the brain of sleep deprived rats. Landis, C.A., Collins, B.J., Cribbs, L.L., Sukhatme, V.P., Bergmann, B.M., Rechtschaffen, A., Smalheiser, N.R. Brain Res. Mol. Brain Res. (1993) [Pubmed]
  10. Changes in the expression of glial glutamate transporters in the rat brain accompanied with morphine dependence and naloxone-precipitated withdrawal. Ozawa, T., Nakagawa, T., Shige, K., Minami, M., Satoh, M. Brain Res. (2001) [Pubmed]
  11. Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump 116-kD subunit, cause recessive distal renal tubular acidosis with preserved hearing. Smith, A.N., Skaug, J., Choate, K.A., Nayir, A., Bakkaloglu, A., Ozen, S., Hulton, S.A., Sanjad, S.A., Al-Sabban, E.A., Lifton, R.P., Scherer, S.W., Karet, F.E. Nat. Genet. (2000) [Pubmed]
  12. Unstable insertion in the 5' flanking region of the cystatin B gene is the most common mutation in progressive myoclonus epilepsy type 1, EPM1. Lafrenière, R.G., Rochefort, D.L., Chrétien, N., Rommens, J.M., Cochius, J.I., Kälviäinen, R., Nousiainen, U., Patry, G., Farrell, K., Söderfeldt, B., Federico, A., Hale, B.R., Cossio, O.H., Sørensen, T., Pouliot, M.A., Kmiec, T., Uldall, P., Janszky, J., Pranzatelli, M.R., Andermann, F., Andermann, E., Rouleau, G.A. Nat. Genet. (1997) [Pubmed]
  13. Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva. Shafritz, A.B., Shore, E.M., Gannon, F.H., Zasloff, M.A., Taub, R., Muenke, M., Kaplan, F.S. N. Engl. J. Med. (1996) [Pubmed]
  14. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Curran, M.E., Splawski, I., Timothy, K.W., Vincent, G.M., Green, E.D., Keating, M.T. Cell (1995) [Pubmed]
  15. The murine pallid mutation is a platelet storage pool disease associated with the protein 4.2 (pallidin) gene. White, R.A., Peters, L.L., Adkison, L.R., Korsgren, C., Cohen, C.M., Lux, S.E. Nat. Genet. (1992) [Pubmed]
  16. Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events. Goldberg, M.A., Gaut, C.C., Bunn, H.F. Blood (1991) [Pubmed]
  17. Stimulation of pS2 expression by diet-derived compounds. Sathyamoorthy, N., Wang, T.T., Phang, J.M. Cancer Res. (1994) [Pubmed]
  18. The high affinity alphaIIb beta3 integrin is involved in invasion of human melanoma cells. Trikha, M., Timar, J., Lundy, S.K., Szekeres, K., Cai, Y., Porter, A.T., Honn, K.V. Cancer Res. (1997) [Pubmed]
  19. Role of tumor cytoskeleton and membrane glycoprotein IRGpIIb/IIIa in platelet adhesion to tumor cell membrane and tumor cell-induced platelet aggregation. Chopra, H., Hatfield, J.S., Chang, Y.S., Grossi, I.M., Fitzgerald, L.A., O'Gara, C.Y., Marnett, L.J., Diglio, C.A., Taylor, J.D., Honn, K.V. Cancer Res. (1988) [Pubmed]
  20. Cloning and characterization of human tumor cell interstitial collagenase. Templeton, N.S., Brown, P.D., Levy, A.T., Margulies, I.M., Liotta, L.A., Stetler-Stevenson, W.G. Cancer Res. (1990) [Pubmed]
  21. Cloning and expression of cDNA for a human thromboxane A2 receptor. Hirata, M., Hayashi, Y., Ushikubi, F., Yokota, Y., Kageyama, R., Nakanishi, S., Narumiya, S. Nature (1991) [Pubmed]
  22. A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination. Rockmill, B., Roeder, G.S. Genes Dev. (1991) [Pubmed]
  23. Thymus-leukemia (TL) antigens of the mouse. Analysis of TL mRNA and TL cDNA TL+ and TL- strains. Chen, Y.T., Obata, Y., Stockert, E., Old, L.J. J. Exp. Med. (1985) [Pubmed]
  24. Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production. Messer, G., Spengler, U., Jung, M.C., Honold, G., Blömer, K., Pape, G.R., Riethmüller, G., Weiss, E.H. J. Exp. Med. (1991) [Pubmed]
  25. Human clusterin gene expression is confined to surviving cells during in vitro programmed cell death. French, L.E., Wohlwend, A., Sappino, A.P., Tschopp, J., Schifferli, J.A. J. Clin. Invest. (1994) [Pubmed]
  26. The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system. Chun, J.J., Schatz, D.G., Oettinger, M.A., Jaenisch, R., Baltimore, D. Cell (1991) [Pubmed]
  27. Thyroid hormone regulates TRH biosynthesis in the paraventricular nucleus of the rat hypothalamus. Segerson, T.P., Kauer, J., Wolfe, H.C., Mobtaker, H., Wu, P., Jackson, I.M., Lechan, R.M. Science (1987) [Pubmed]
  28. Differential accumulation of U1 and U4 small nuclear RNAs during Xenopus development. Lund, E., Dahlberg, J.E. Genes Dev. (1987) [Pubmed]
  29. Production of tumor necrosis factor/cachectin by human T cell lines and peripheral blood T lymphocytes stimulated by phorbol myristate acetate and anti-CD3 antibody. Sung, S.S., Bjorndahl, J.M., Wang, C.Y., Kao, H.T., Fu, S.M. J. Exp. Med. (1988) [Pubmed]
  30. Constitutive expression of pore-forming protein in peripheral blood gamma/delta T cells: implication for their cytotoxic role in vivo. Nakata, M., Smyth, M.J., Norihisa, Y., Kawasaki, A., Shinkai, Y., Okumura, K., Yagita, H. J. Exp. Med. (1990) [Pubmed]
  31. Two structural genes on different chromosomes are required for encoding the major subunit of human red cell glucose-6-phosphate dehydrogenase. Kanno, H., Huang, I.Y., Kan, Y.W., Yoshida, A. Cell (1989) [Pubmed]
  32. Transposon tagging and molecular analysis of the maize regulatory locus opaque-2. Schmidt, R.J., Burr, F.A., Burr, B. Science (1987) [Pubmed]
  33. Glucocorticoids induce the expression of CD8 alpha chains on concanavalin A-activated rat CD4+ T cells: induction is inhibited by rat recombinant interleukin 4. Ramirez, F., McKnight, A.J., Silva, A., Mason, D. J. Exp. Med. (1992) [Pubmed]
  34. Imbalanced MHC class II molecule expression at surface of murine B cell lymphomas. Zijlstra, M., Vasmel, W.L., Voormanns, M., de Goede, R.E., Schoenmakers, H.J., Nieland, J., Slater, R.M., Melief, C.J. J. Exp. Med. (1986) [Pubmed]
  35. The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose. Kanai, Y., Lee, W.S., You, G., Brown, D., Hediger, M.A. J. Clin. Invest. (1994) [Pubmed]
  36. Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death. Braun, T., Rudnicki, M.A., Arnold, H.H., Jaenisch, R. Cell (1992) [Pubmed]
  37. Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids. Yang, Y., Merćep, M., Ware, C.F., Ashwell, J.D. J. Exp. Med. (1995) [Pubmed]
  38. Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway. Miller, D.M., Rahill, B.M., Boss, J.M., Lairmore, M.D., Durbin, J.E., Waldman, J.W., Sedmak, D.D. J. Exp. Med. (1998) [Pubmed]
  39. Enhanced interleukin-8 release and gene expression in macrophages after exposure to Mycobacterium tuberculosis and its components. Zhang, Y., Broser, M., Cohen, H., Bodkin, M., Law, K., Reibman, J., Rom, W.N. J. Clin. Invest. (1995) [Pubmed]
  40. Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lung. Standiford, T.J., Kunkel, S.L., Basha, M.A., Chensue, S.W., Lynch, J.P., Toews, G.B., Westwick, J., Strieter, R.M. J. Clin. Invest. (1990) [Pubmed]
  41. The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn. Chu, J.L., Drappa, J., Parnassa, A., Elkon, K.B. J. Exp. Med. (1993) [Pubmed]
  42. Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors. Caligiuri, M.A., Zmuidzinas, A., Manley, T.J., Levine, H., Smith, K.A., Ritz, J. J. Exp. Med. (1990) [Pubmed]
  43. Expression of 92-kD type IV collagenase/gelatinase (gelatinase B) in osteoarthritic cartilage and its induction in normal human articular cartilage by interleukin 1. Mohtai, M., Smith, R.L., Schurman, D.J., Tsuji, Y., Torti, F.M., Hutchinson, N.I., Stetler-Stevenson, W.G., Goldberg, G.I. J. Clin. Invest. (1993) [Pubmed]
  44. Renal nerves modulate renin gene expression in the developing rat kidney with ureteral obstruction. el-Dahr, S.S., Gomez, R.A., Gray, M.S., Peach, M.J., Carey, R.M., Chevalier, R.L. J. Clin. Invest. (1991) [Pubmed]
  45. Synaptoporin, a novel putative channel protein of synaptic vesicles. Knaus, P., Marquèze-Pouey, B., Scherer, H., Betz, H. Neuron (1990) [Pubmed]
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