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Gene Review:

PF0676 - carbamate kinase-like carbamoyl phosphate...

Pyrococcus furiosus DSM 3638

Massant, J. et al., Durbecq, V. et al., Marco-Marín, C. et al.

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High impact information on PF0676

The carbamate kinase-like carbamoyl phosphate synthetase of the hyperthermophilic archaeon Pyrococcus furiosus, a missing link in the evolution of carbamoyl phosphate biosynthesis [1].
Metabolic channeling of carbamoyl phosphate, a thermolabile intermediate: evidence for physical interaction between carbamate kinase-like carbamoyl-phosphate synthetase and ornithine carbamoyltransferase from the hyperthermophile Pyrococcus furiosus [2].
The UMPK polypeptide exhibits the amino acid kinase family (AAKF) fold that has been reported in carbamate kinase and acetylglutamate kinase [3].

References

The carbamate kinase-like carbamoyl phosphate synthetase of the hyperthermophilic archaeon Pyrococcus furiosus, a missing link in the evolution of carbamoyl phosphate biosynthesis. Durbecq, V., Legrain, C., Roovers, M., Piérard, A., Glansdorff, N. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
Metabolic channeling of carbamoyl phosphate, a thermolabile intermediate: evidence for physical interaction between carbamate kinase-like carbamoyl-phosphate synthetase and ornithine carbamoyltransferase from the hyperthermophile Pyrococcus furiosus. Massant, J., Verstreken, P., Durbecq, V., Kholti, A., Legrain, C., Beeckmans, S., Cornelis, P., Glansdorff, N. J. Biol. Chem. (2002) [Pubmed]
The crystal structure of Pyrococcus furiosus UMP kinase provides insight into catalysis and regulation in microbial pyrimidine nucleotide biosynthesis. Marco-Marín, C., Gil-Ortiz, F., Rubio, V. J. Mol. Biol. (2005) [Pubmed]

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