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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Gpm6b  -  glycoprotein m6b

Mus musculus

Synonyms: AI593561, Gpm6, M6B, M6b, Neuronal membrane glycoprotein M6-b
 
 
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High impact information on Gpm6b

  • Structural analysis and the phylogenic tree showed that rat Rhombex-29 is homologous to the major CNS myelin protein PLP/DM20-M6 family and belongs to the intermediate type between mouse M6b and shark DMgamma [1].
  • M6b-2 differs from the previously published M6b by a novel 40-amino acid insertion which is characterised by a high proline content, two casein kinase, and one tyrosine kinase consensus sequences [2].
  • In contrast, M6b was expressed at early embryonic stages in the ventricular zone of the spinal cord, and later during development in both neurons and glia [3].

References

  1. Rhombex-29, a novel gene of the PLP/DM20-M6 family cloned from rat medulla oblongata by differential display. Shimokawa, N., Miura, M. J. Neurosci. Res. (2000) [Pubmed]
  2. Molecular cloning and transfection studies of M6b-2, a novel splice variant of a member of the PLP-DM20/M6 gene family. Vouyiouklis, D.A., Werner, H., Griffiths, I.R., Stewart, G.J., Armin-Nave, K., Thomson, C.E. J. Neurosci. Res. (1998) [Pubmed]
  3. Expression of members of the proteolipid protein gene family in the developing murine central nervous system. Yan, Y., Narayanan, V., Lagenaur, C. J. Comp. Neurol. (1996) [Pubmed]
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