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MeSH Review

Spinal Cord

 
 
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Disease relevance of Spinal Cord

 

Psychiatry related information on Spinal Cord

  • Oral sildenafil is an effective and well-tolerated treatment for erectile dysfunction caused by spinal cord injury [6].
  • It was shown that the descending noradrenergic systems were facilitatory to the motor system, and that alpha 1-antagonistic action at the spinal cord and alpha 2-agonistic action at the brainstem inhibited spinal motor activity by blocking spinal alpha 1-receptors and by reducing the release of noradrenaline in the spinal cord, respectively [7].
  • The decrease in tail-flick latency suggests that pain threshold was decreased, and the dramatic behavioural effects seen at high doses suggest that an excess of substance P in the spinal cord is capable of producing a painful sensation [8].
  • Site of injury-directed induction of heme oxygenase-1 and -2 in experimental spinal cord injury: differential functions in neuronal defense mechanisms [9]?
  • BACKGROUND: A priori hypothesis: vaginal and/or cervical self-stimulation will not produce perceptual responses in women with "complete" spinal cord injury (SCI) at or above the highest level of entry of the hypogastric nerves (T10-12) but will produce perceptual responses if SCI is below T-10 [10].
 

High impact information on Spinal Cord

 

Chemical compound and disease context of Spinal Cord

 

Biological context of Spinal Cord

 

Anatomical context of Spinal Cord

 

Associations of Spinal Cord with chemical compounds

  • We conclude that in patients with acute spinal-cord injury, treatment with methylprednisolone in the dose used in this study improves neurologic recovery when the medication is given in the first eight hours [30].
  • Some forms of dystonia respond to the intrathecal administration of baclofen, a specific gamma-aminobutyric acid-receptor (type B) agonist that inhibits sensory input to the neurons of the spinal cord [31].
  • A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord [32].
  • These results show that netrin-1 is a chemotropic factor expressed by floor plate cells and suggest that the two netrin proteins guide commissural axons in the developing spinal cord [33].
  • Moreover, studies using extracellular single-cell recording techniques indicate that serotonin in small amounts facilitates synaptically or glutamate-induced excitation of mammalian motoneurones in the facial nucleus and spinal cord [34].
 

Gene context of Spinal Cord

  • It is expressed principally in the brain and spinal cord, and is similar in overall structure to the Dp116 dystrophin isoform [35].
  • ALS2 is expressed in various tissues and cells, including neurons throughout the brain and spinal cord, and encodes a protein containing multiple domains that have homology to RanGEF as well as RhoGEF [36].
  • Substance P is synthesized by small-diameter sensory 'pain' fibres, and release of the peptide into the dorsal horn of the spinal cord following intense peripheral stimulation promotes central hyperexcitability and increased sensitivity to pain [37].
  • In adult rats, injection of NT-3 (but not BDNF) into the lesioned spinal cord increases the regenerative sprouting of the transected CST [38].
  • Finally, we show that netrin-1-dependent outgrowth of dorsal spinal cord axons directly involves A2b [39].
 

Analytical, diagnostic and therapeutic context of Spinal Cord

References

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  13. The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. Tsai, H.H., Frost, E., To, V., Robinson, S., Ffrench-Constant, C., Geertman, R., Ransohoff, R.M., Miller, R.H. Cell (2002) [Pubmed]
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