Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Mtd - F420-dependent methylenetetrahydromethanop...

Methanopyrus kandleri AV19

Hagemeier, C.H. et al., Klein, A.R. et al., Warkentin, E. et al.

Warkentin, Hagemeier, Shima, Thauer, Ermler,

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Disease relevance of Mtd

The mtd gene encoding coenzyme-F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase (Mtd) in the hyperthermophilic Methanopyrus kandleri has been cloned, sequenced and functionally overexpressed in Escherichia coli [1].

High impact information on Mtd

The structure of F420-dependent methylenetetrahydromethanopterin dehydrogenase: a crystallographic 'superstructure' of the selenomethionine-labelled protein crystal structure [2].
Coenzyme F(420)-dependent methylenetetrahydromethanopterin dehydrogenase (Mtd) is an enzyme involved in methanogenic energy metabolism which reversibly catalyzes the reduction of methenyltetrahydromethanopterin (methenyl-H(4)MPT(+)) to methylenetetrahydromethanopterin (methylene-H(4)MPT) [3].

Associations of Mtd with chemical compounds

Coenzyme F420-dependent methylenetetrahydromethanopterin dehydrogenase from Methanopyrus kandleri: the selenomethionine-labelled and non-labelled enzyme crystallized in two different forms [3].

References

Overexpression of the coenzyme-F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase gene from the hyperthermophilic Methanopyrus kandleri. Klein, A.R., Thauer, R.K. Eur. J. Biochem. (1997) [Pubmed]
The structure of F420-dependent methylenetetrahydromethanopterin dehydrogenase: a crystallographic 'superstructure' of the selenomethionine-labelled protein crystal structure. Warkentin, E., Hagemeier, C.H., Shima, S., Thauer, R.K., Ermler, U. Acta Crystallogr. D Biol. Crystallogr. (2005) [Pubmed]
Coenzyme F420-dependent methylenetetrahydromethanopterin dehydrogenase from Methanopyrus kandleri: the selenomethionine-labelled and non-labelled enzyme crystallized in two different forms. Hagemeier, C.H., Shima, S., Warkentin, E., Thauer, R.K., Ermler, U. Acta Crystallogr. D Biol. Crystallogr. (2003) [Pubmed]

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