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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ORF13  -  thymidylate synthase

Human herpesvirus 3

 
 
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High impact information on ORF13

  • Identification of a thymidylate synthase gene within the genome of Chilo iridescent virus [1].
  • The thymidylate synthase (TS, EC 2.1.1.45) is essential for the de novo synthesis of dTMP in pro- and eucaryotic organisms [1].
  • In contrast to these results, TS inhibitor, 5-fluorodeoxyuridine (FUDR), had higher antiviral activity to the YSR strain than to the YS strain [2].

References

  1. Identification of a thymidylate synthase gene within the genome of Chilo iridescent virus. Müller, K., Tidona, C.A., Bahr, U., Darai, G. Virus Genes (1998) [Pubmed]
  2. Antiviral activity of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil against thymidine kinase negative strains of varicella-zoster virus. Kawai, H., Yoshida, I., Suzutani, T. Microbiol. Immunol. (1993) [Pubmed]
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